This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009].
MacDonald, Longacre, Kendrick: "Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells." in: Archives of biochemistry and biophysics, Vol. 488, Issue 2, pp. 100-4, (2009) (PubMed).
Zoccarato, Cavallini, Alexandre: "Succinate is the controller of O2-/H2O2 release at mitochondrial complex I : negative modulation by malate, positive by cyanide." in: Journal of bioenergetics and biomembranes, Vol. 41, Issue 4, pp. 387-93, (2009) (PubMed).
Brown, Longacre, Hasan, Kendrick, Stoker, Macdonald: "Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line." in: The Journal of biological chemistry, Vol. 284, Issue 51, pp. 35359-67, (2009) (PubMed).
Tsuyuguchi, Kawasumi, Takashima, Tsuyuguchi, Kishimoto: "Mycobacterium avium-Mycobacterium intracellular complex-induced suppression of T-cell proliferation in vitro by regulation of monocyte accessory cell activity." in: Infection and immunity, Vol. 58, Issue 5, pp. 1369-78, (1990) (PubMed).