anti-IGFBP3 (IGFBP3) 抗体产品概述

Human Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) interaction partners

1. insulin-like growth factor binding protein 3 promoted human bone marrow mesenchymal stem cell migration in a Transforming Growth Factor beta Receptor I/II- and chemokine (C-C motif) receptor 2-dependent mechanisms.

2. Data show that the serum insulin like growth factor 1 (IGF-1) concentrations were within the lower normal range (41.7% cases), and 58.3% results were below the normal reference range, and the average serum insulin-like growth factor binding protein type 3 (IGFBP-3 ) levels were within the lower normal range.

3. Data provide evidence that up-regulation of IGFBP3 might mediate brain metastasis in lung adenocarcinoma.

4. we aimed to evaluate serum levels of IGF-1, IGF-2 and IGF-binding protein 3 (IGF-BP3) before and after standard treatment in patients with advanced non-small cell lung cancer (NSCLC) and their prognostic and predictive correlations.

5. There was an additive effect of the alleles in the four genes associated with good growth response. For rs3110697 within IGFBP3, rs1045992 in CYP19A1 and rs2888586 in SOS1, the variant associated with better growth response showed higher transcriptional activity with r-hGH treatment

6. Higher IGFBP3 is associated with increased incidence of colorectal cancer in older men independently of IGF1

7. Residues 215-232 of IGFBP3 bind either hyaluronan or humanin, but not both. Hyaluronan has a weaker affinity for this region that humanin.

8. study of association of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer [Meta-analysis]

9. Findings suggest a PARP polymerase (PARP)-dependent role for non-POU domain containing, octamer-binding protein NONO (NONO) and splicing factor proline-glutamine rich protein (SFPQ) in insulin-like growth factor binding protein 3 (IGFBP-3)-dependent DNA double-strand break (DSB) repair.

10. This study is one of the first to show that the IGFBP3 polymorphism may have an influence on serum levels, and that the C allele of rs2854744 is associated with a reduced risk of acromegaly.

11. Findings suggested that TSPY1 might bind to the region from -225 to -205 bp of the IGFBP3 promoter to suppress the transcriptional activity of IGFBP3 decreasing its expression.

12. genotypes CA(19)/CA(19) and CA(19)/CA(19) + CA(>19)/CA(n) of the IGF-1 CA(n) may be considered a risk for endometrial polyp, whereas the genotypes CG and CG + GG of IGFBP3 rs2854746 polymorphism have an inverse effect of endometrial polyp risk.

13. The serum concentrations of IGF-1 and insulin-like growth factor-binding protein 3 (IGFBP-3) was assessed in patients with Crohn disease and with ulcerative colitis.

14. Studied association of insulin like growth factor 1 (IGF-I), insulin like growth factor binding protein 3 (IGFBP-3), body size and milk consumption in an Indian cohort from birth to 6 years.

15. PKA requires active IGFBP-3 and SIRT1 to inhibit HMGB1 inflammatory actions in the retina vasculature. Activation of these pathways may offer new targets for therapy of retinal inflammation.

16. The serum level of IGFBP-3 was down-regulated and the IGF-1 activity was up-regulated by 4-week moderate aerobic exercise plus diet control in female obese youths and adolescents.

17. Our data suggest a role of the IGF system, particularly IGFBP-3, in TDLU involution of the normal breast, a breast cancer risk factor, among Caucasian and AA women.

18. In cancerous tissues of colorectal cancer (CRC) patients, the miR197 level was inversely correlated with the expression of IGFBP3, which indicated that miR197 may modulate cell migration and invasion by targeting IGFBP3 in CRC patients.

19. Together findings presented here recognize an inherent role of MTA1 as a modifier of DNMT3a and IGFBP3 expression, and consequently, the role of MTA1-DNMT3a-IGFBP3 axis in breast cancer progression.

20. Peripheral totalIGF-1 and IGFBP-3 were associated with better performance in attention, visuospatial, and global cognitive domains, independent of the gait speed.

Mouse (Murine) Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) interaction partners

1. Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature.

2. IGFBP-3 inhibits osteoblast differentiation through the BMP-2 signal pathway.

3. The results of this study provide an immune-based mechanism by which host IGFBP3 may promote breast tumor growth in the EO771 murine breast cancer model, and suggest that targeting IGFBP-3 might make a novel contribution to immune therapy for breast cancer.

4. Igfbp3-null mouse model was generated in combination with Kras(G12D) to compare the tumor burden. Then, IGF-dependent signaling was assessed after expressing wild-type or a mutant IGFBP3 without IGF binding capacity in non-small cell lung cancer (NSCLC) cells

5. endogenous (circulating and/or stromal) IGFBP-3 is stimulatory to adipose tissue expansion and enhances mammary tumor growth in immune-competent mice, potentially by suppressing T-cell infiltration into tumors.

6. High Igfbp3 expression is associated with skin squamous cell carcinoma.

7. The study shows that the anti-tumoral effect of IGFBP-3 is due to inhibition of the Wnt pathway and depends upon the presence of CD44, a receptor protein known to modulate Wnt signaling.

8. IGFBP-3 influences severity of DSS-induced colitis.

9. our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain

10. IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.

11. An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.

12. Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.

13. Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC migration.

14. Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development.

15. IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.

16. IGFBP-3 activates inhibitory Smad signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFbeta.

17. Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3.

18. IGFBP-3 positively and negatively impacts on IGF1-induced lung cancer development.

19. Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3.

20. Mice genetically deficient in IGFBP-3 have weaker growth of primary prostate tumors but higher incidence of metastases.

Cow (Bovine) Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) interaction partners

1. The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3.

2. These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 to the cytoplasm where it exerts its apoptotic effect.

3. The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle.

4. spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies

5. stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK pathways in bovine mammary epithelial cells

6. Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of IGFBP-3

7. GH, IGF-I and IGF-IBP3 regulated the growth and development traits in different growth period.

8. delivery of insulin-like growth factor-1 (IGF-1, delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1, its receptor (IGF-1R), and a well known IGF-1 binding protein (IGFBP-3) by articular chondrocytes

9. Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction

10. Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.

Zebrafish Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) interaction partners

1. insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 in zebrafish embryos

2. IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.

Pig (Porcine) Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) interaction partners

1. IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.

2. Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis

3. Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.

4. cloning and sequencing; regulation of IGFBP-3 transcription by FSH suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I

5. Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK pathways.

6. TAF4b may thus be the TFIID component that binds to the TBP site on the IGFBP-3 promoter and is essential for FSH induction of IGFBP-3.

7. The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds.

8. allelic frequency of TAT in Chinese breeds was over 50%; allelic frequency of GGC was over 50% in all European breeds. TAT/TAT pigs scored higher in meat color than GGC/GGC pigs. results implied that IGFBP-3 may affect meat quality & carcass traits.

Horse (Equine) Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) interaction partners

1. Data suggest that metabolism of IGFBP3, IGF1 (insulin-like growth factor I), and IGF2 (insulin-like growth factor II) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).