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Human Polyclonal GRK4 Primary Antibody for IHC (p), WB - ABIN1882085
Premont, Macrae, Stoffel, Chung, Pitcher, Ambrose, Inglese, MacDonald, Lefkowitz: Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. in The Journal of biological chemistry 1996
Show all 6 Pubmed References
On normal salt diet, renal CuZnSOD (显示 SOD1 抗体) and ECSOD (显示 SOD3 抗体) proteins were similar but renal MnSOD (显示 SOD2 抗体) was lower in hGRK4g486V than Non-T mice and remained low on high salt diet. hGRK4gammawild-type mice were normotensive and hGRK4g142V mice were hypertensive but both were salt-resistant and in normal redox balance. Chronic tempol treatment partially prevented the salt-sensitivity of hGRK4g486V mice.
A novel function of GRK4 on triggering a p53 (显示 TP53 抗体)-independent cellular senescence, which involves an intricate signaling network.
the association between GRK4(142V) and a larger decrease in blood pressure with angiotensin receptor blockers in hypertensive patients.
Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215-2.745, P=0.004) but not in East Asians and Africans. [meta-analysis]
Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (显示 NMUR1 抗体) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C-tail responsible for this GRK function.
hGRK4gamma(142V) phosphorylates histone deacetylase (显示 HDAC1 抗体) type 1 and promotes its nuclear export to the cytoplasm, resulting in increased AT1R (显示 AGTR1 抗体) expression and greater pressor response to angiotensin II.
A high sodium intake markedly increased the obesity risk in variants of GRK4 A486V regardless of sex amongst Korean children.
The C-terminal region of FMRP (显示 FMR1 抗体) interacts with a domain of GRK4 mRNA that is folded in four stem loops.
GRK4alpha is more similar to GRK2 (显示 ADRBK1 抗体) than GRK6 (显示 GRK6 抗体). A fully ordered kinase C-tail reveals interactions linking the C-tail with important determinants of kinase activity, including the alphaB helix, alphaD helix, and the P-loop
GRK4 genetic polymorphism plays an important role in the regulation of hypertension.
The role of GRK2 (显示 ADRBK1 抗体) in chronic ET-1 (显示 EDN1 抗体)-induced insulin (显示 INS 抗体) resistance was investigated.
GRK2 (显示 ADRBK1 抗体) inhibits WNT (显示 WNT2 抗体) signaling in osteoblasts
Data (including data from transgenic flies) suggest that SNF1A is involved in neuroprotection in this species; AMPK activation in glia (but not neurons) reduces severity of ionic disruption and prolongs recovery of electrical activity in brains of flies in starvation-induced anoxia.
AMPK can function outside of its canonical nutrient-sensing role in specific developmental contexts.
The significance of these findings is that AMPK is important in the regulation of glucagon (显示 GCG 抗体) signaling, suggesting that the organization of metabolic networks is highly conserved and that AMPK plays a prominent role in these networks.
Loss of AMPK activity exacerbates neuronal loss and associated phenotypes in parkin (显示 PARK2 抗体) and LRRK transgenic flies.
Data suggest that that an Sgt1 (显示 SUGT1 抗体)/Hsp90 (显示 HSP90 抗体)-LKB1 (显示 STK11 抗体)-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors.
AMPK gamma and alpha mutants altered lipid metabolism and showed persistent starvation behaviors.
AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut (显示 GUSB 抗体)
These results raise the possibility that muscle is one of major tissues in which AMPK plays a critical role on longevity and stress resistance.
activated by AMP (显示 AMPH 抗体) in cell-free assays and by stresses that deplete ATP; the phosphorylated DmAMPK alpha subunit (显示 POLG 抗体) was mainly detected in the nucleus
results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.
, G protein-coupled receptor kinase 2, groucho gene related
, g protein-coupled receptor kinase GRK4
, 5'monophosphate-activated kinase
, AMP-activated kinase
, AMP-activated protein kinase
, AMP-dependent kinase
, G protein-coupled receptor kinase 4
, SNF/AMP-activated protein S/T kinase gamma subunit
, adenosine monophosphate-activated protein kinase
, G-protein-coupled receptor kinase 2-like