This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Shin, Yoon, Chun, Shin, Lee, Oh, Park: "Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A." in: Cell death & disease, Vol. 5, pp. e1490, (2014) (PubMed).
Davis, Newcomb, Moskovitz, Wingfield, Stahl, Kaufman, Fales, Levine, Yarchoan: "HIV-2 protease is inactivated after oxidation at the dimer interface and activity can be partly restored with methionine sulphoxide reductase." in: The Biochemical journal, Vol. 346 Pt 2, pp. 305-11, (2000) (PubMed).
Aliases for MSRA 抗体
methionine sulfoxide reductase A (Msra) 抗体 methionine sulfoxide reductase A (MSRA) 抗体 2310045J23Rik 抗体 6530413P12Rik 抗体 MSR-A 抗体 PMSR 抗体