MSK1 抗体
(Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto- oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro- inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti- inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| MSK1 抗体 (AA 752-802) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (AA 700-800) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer376) | 人, 小鼠 | 兔 Polyclonal |
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| Recombinant MSK1 抗体 (pSer376) | 人 | 兔 Monoclonal |
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| MSK1 抗体 (pSer212) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer376) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer212) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer212) | 人, 小鼠 | 兔 Polyclonal |
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| MSK1 抗体 (Tyr453) | 人, 小鼠 | 兔 Polyclonal |
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| MSK1 抗体 (AA 331-380) | 人, 小鼠 | 兔 Polyclonal |
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| MSK1 抗体 (AA 372-470) | 人 | 小鼠 Monoclonal |
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| MSK1 抗体 (Center) | 人, 小鼠, 大鼠, 猴, Cow, 犬, Pig, 兔, 小鸡 | 兔 Polyclonal |
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| MSK1 抗体 (pSer212) (Biotin) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer212) (FITC) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer212) (HRP) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer376) (AbBy Fluor® 350) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer212) (Cy5) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer212) (Cy5.5) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pThr581) (Cy3) | 人 | 兔 Polyclonal |
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| MSK1 抗体 (pSer212) (Cy7) | 人 | 兔 Polyclonal |
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Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- WB (Western Blotting: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- IHC (fp) (Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 752-802
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 700-800
Primary Antibody
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pSer376
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Monoclonal
- 克隆
- 2F3
- 标记
- unconjugated
- 蛋白类型
- Recombinant Antibody
- 抗体亚型
- IgG
- 抗原表位
- pSer376
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- IF (Immunofluorescence: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pSer376
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- ELISA (ELISA: 所列应用)
- IF (Immunofluorescence: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Tyr453
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 331-380
Primary Antibody
- ELISA (ELISA: 有验证图片)
- IF (Immunofluorescence: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 1G7
- 标记
- unconjugated
- 抗体亚型
- IgG2a
- 抗原表位
- AA 372-470
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- 适用
- 人, 小鼠, 大鼠, 猴, Cow, 犬, Pig, 兔, 小鸡
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- Center
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Biotin
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- AbBy Fluor® 350
- 抗体亚型
- IgG
- 抗原表位
- pSer376
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Cy5
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Cy5.5
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Cy3
- 抗体亚型
- IgG
- 抗原表位
- pThr581
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Cy7
- 抗体亚型
- IgG
- 抗原表位
- pSer212
Latest Publications for our MSK1 抗体
: "Aloe emodin suppresses EGF‑induced neoplastic cell transformation by inhibiting the ERK/MSK1 and AKT/GSK3β signaling pathways." in: Molecular medicine reports, Vol. 18, Issue 6, pp. 5215-5220, (2019) (PubMed).
: "MSK1 activity is controlled by multiple phosphorylation sites." in: The Biochemical journal, Vol. 387, Issue Pt 2, pp. 507-17, (2005) (PubMed).
: "ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions." in: Microbiology and molecular biology reviews : MMBR, Vol. 68, Issue 2, pp. 320-44, (2004) (PubMed).
: "Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1." in: Carcinogenesis, Vol. 25, Issue 7, pp. 1165-75, (2004) (PubMed).
: "Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways." in: The Journal of biological chemistry, Vol. 279, Issue 29, pp. 30474-9, (2004) (PubMed).
: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).
: "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts." in: Molecular and cellular biology, Vol. 22, Issue 8, pp. 2871-81, (2002) (PubMed).
: "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-->q32.1 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 87, Issue 3-4, pp. 261-2, (2000) (PubMed).
: "Cloning and characterization of RLPK, a novel RSK-related protein kinase." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 1026-32, (1999) (PubMed).
: "MSK1 activity is controlled by multiple phosphorylation sites." in: The Biochemical journal, Vol. 387, Issue Pt 2, pp. 507-17, (2005) (PubMed).
: "ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions." in: Microbiology and molecular biology reviews : MMBR, Vol. 68, Issue 2, pp. 320-44, (2004) (PubMed).
: "Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1." in: Carcinogenesis, Vol. 25, Issue 7, pp. 1165-75, (2004) (PubMed).
: "Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways." in: The Journal of biological chemistry, Vol. 279, Issue 29, pp. 30474-9, (2004) (PubMed).
: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).
: "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts." in: Molecular and cellular biology, Vol. 22, Issue 8, pp. 2871-81, (2002) (PubMed).
: "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-->q32.1 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 87, Issue 3-4, pp. 261-2, (2000) (PubMed).
: "Cloning and characterization of RLPK, a novel RSK-related protein kinase." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 1026-32, (1999) (PubMed).
Aliases for MSK1 抗体
ribosomal protein S6 kinase A5 (RPS6KA5) 抗体ribosomal protein S6 kinase, polypeptide 5 (Rps6ka5) 抗体
ribosomal protein S6 kinase A5 (Rps6ka5) 抗体
3110005L17Rik 抗体
6330404E13Rik 抗体
AI854034 抗体
MSK1 抗体
Msk1 抗体
MSPK1 抗体
RLPK 抗体
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