MSH alpha 产品
(MSH alpha)
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This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
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MSH alpha ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Recommended MSH alpha 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN735323
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
Cat. No.
ABIN735325
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB
Validations
Cat. No.
ABIN2809652
Quantity
100 μL
Datasheet
Datasheet
Recommended MSH alpha ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
- (6)
- (1)
Cat. No.
ABIN6957888
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957889
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6974470
Quantity
96 tests
Datasheet
Datasheet
Recommended MSH alpha 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Source
Synthetic
Validations
- (2)
Cat. No.
ABIN1878818
Quantity
200 μg
Datasheet
Datasheet
Latest Publications for our MSH alpha Products
: "Alcohol Withdrawal and Proopiomelanocortin Neuropeptides in an Animal Model of Alcohol Dependence." in: Neuropsychobiology, Vol. 78, Issue 3, pp. 118-127, (2020) (PubMed).: "Intermedin alleviates the inflammatory response and stabilizes the endothelial barrier in LPS-induced ARDS through the PI3K/Akt/eNOS signaling pathway." in: International immunopharmacology, Vol. 88, pp. 106951, (2020) (PubMed).
: "Mechanisms of sustained long-term weight loss after RYGB: α-MSH is a key factor." in: Neuropeptides, Vol. 69, pp. 60-65, (2019) (PubMed).
: "UVB-inhibited H19 activates melanogenesis by paracrine effects." in: Experimental dermatology, Vol. 27, Issue 10, pp. 1120-1125, (2018) (PubMed).
: "Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses." in: Cell stem cell, Vol. 22, Issue 5, pp. 698-712.e9, (2018) (PubMed).
: "Epigenetic alterations of the POMC promoter in tobacco dependence." in: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 28, Issue 7, pp. 875-879, (2018) (PubMed).
: "Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives." in: Nature communications, Vol. 8, Issue 1, pp. 219, (2017) (PubMed).
: "Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity." in: Endocrinology, Vol. 158, Issue 1, pp. 41-55, (2017) (PubMed).
: "Pharmacological induction of skin pigmentation unveils the neuroendocrine circuit regulated by light." in: Pigment cell & melanoma research, Vol. 29, Issue 2, pp. 186-98, (2016) (PubMed).
: "Narrow-band ultraviolet B radiation induces the expression of β-endorphin in human skin in vivo." in: Journal of photochemistry and photobiology. B, Biology, Vol. 155, pp. 104-8, (2016) (PubMed).
Synonyms and alternative names related to MSH alpha
proopiomelanocortin (POMC), STAM binding protein (STAMBP), pro-opiomelanocortin-alpha (Pomc), proopiomelanocortin (Pomc), ACTH, alpha-MSH, alphaMSH, AMSH, BE, Beta-LPH, beta-MSH, CLIP, Clip, Gamma-LPH, gamma-MSH, LPH, MSH, NPP, Npp, POC, Pomc-1, Pomc1, Pomc2Protein level used designations for MSH alpha
- adrenocorticotropic hormone
- adrenocorticotropin
- alpha-MSH
- alpha-melanocyte-stimulating hormone
- beta-LPH
- beta-MSH
- beta-endorphin
- beta-melanocyte-stimulating hormone
- corticotropin-like intermediary peptide
- corticotropin-lipotropin
- gamma-LPH
- gamma-MSH
- lipotropin beta
- lipotropin gamma
- melanotropin alpha
- melanotropin beta
- melanotropin gamma
- met-enkephalin
- opiomelanocortin prepropeptide
- pro-ACTH-endorphin
- pro-opiomelanocortin
- proopiomelanocortin preproprotein
- STAM-binding protein
- associated molecule with the SH3 domain of STAM
- endosome-associated ubiquitin isopeptidase
- alpha-melanocyte stimulating hormone
- beta-lipotropin
- beta-melanocyte stimulating hormone
- proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
- adrenal corticotropic hormone
- pro-opiomelanocortin-alpha
- proopiomelanocortin, beta (endorphin, beta)
- proopoimelanocortin, beta (endorphin, beta)
- Corticotropin-lipotropin
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