The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008].
Santidrián, González-Gironès, Iglesias-Serret, Coll-Mulet, Cosialls, de Frias, Campàs, González-Barca, Alonso, Labi, Viollet, Benito, Pons, Villunger, Gil: "AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells." in: Blood, Vol. 116, Issue 16, pp. 3023-32, (2010) (PubMed).
Heiser, Labi, Erlacher, Villunger: "The Bcl-2 protein family and its role in the development of neoplastic disease." in: Experimental gerontology, Vol. 39, Issue 8, pp. 1125-35, (2004) (PubMed).
Cory, Huang, Adams: "The Bcl-2 family: roles in cell survival and oncogenesis." in: Oncogene, Vol. 22, Issue 53, pp. 8590-607, (2003) (PubMed).
Tan, Tan, Chan, Yee, Bevort, Ang, Yu: "MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains." in: The Journal of biological chemistry, Vol. 276, Issue 4, pp. 2802-7, (2001) (PubMed).
Lockshin, Osborne, Zakeri: "Cell death in the third millennium." in: Cell death and differentiation, Vol. 7, Issue 1, pp. 2-7, (2000) (PubMed).
Aliases for MOAP1 抗体
modulator of apoptosis 1 (MOAP1) 抗体 modulator of apoptosis 1 S homeolog (moap1.S) 抗体 modulator of apoptosis 1 (Moap1) 抗体 AA987038 抗体 MAP-1 抗体 Map-1 抗体 MOAP1 抗体 PNMA4 抗体 Pnma4 抗体