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MMP25 产品

(Matrix Metallopeptidase 25 (MMP25))
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008].

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Featured MMP25 Categories

MMP25 抗体

High quality antibodies with extensive validation data.

MMP25 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

MMP25 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MMP25 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN7268422
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (5)
Cat. No. ABIN7258762
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7242293
Quantity 200 μL
Datasheet Datasheet

Recommended MMP25 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957696
Quantity 96 tests
Datasheet Datasheet

Recommended MMP25 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3083812
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3121955
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395290
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MMP25 Products

Zhao, Sohail, Sun, Shi, Kim, Mobashery, Fridman: "Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25)." in: The Journal of biological chemistry, Vol. 283, Issue 50, pp. 35023-32, (2008) (PubMed).

Sun, Weber, Sohail, Bernardo, Toth, Zhao, Turner, Fridman: "MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties." in: The Journal of biological chemistry, Vol. 282, Issue 30, pp. 21998-2010, (2007) (PubMed).

Matsuda, Itoh, Koshikawa, Akizawa, Yana, Seiki: "Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36350-7, (2003) (PubMed).

Velasco, Cal, Merlos-Suárez, Ferrando, Alvarez, Nakano, Arribas, López-Otín: "Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors." in: Cancer research, Vol. 60, Issue 4, pp. 877-82, (2000) (PubMed).

Synonyms and alternative names related to MMP25

matrix metallopeptidase 25 (MMP25), matrix metallopeptidase 25 (Mmp25), F730048C11Rik, Leukolysin, MMP-25, MMP20, MMP20A, MMPL1, MT-MMP 6, MT-MMP6, MT6-MMP, MT6MMP, MTMMP6

Protein level used designations for MMP25

  • leukolysin
  • matrix metallopeptidase-like 1
  • matrix metalloproteinase 20
  • matrix metalloproteinase 25
  • matrix metalloproteinase-25
  • matrix metalloproteinase-like 1
  • membrane-type 6 matrix metalloproteinase
  • membrane-type matrix metalloproteinase 6
  • membrane-type-6 matrix metalloproteinase
  • MMP-25
  • LOW QUALITY PROTEIN: matrix metalloproteinase-25
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