MLL/KMT2A 抗体
(Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010].
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Latest Publications for our MLL/KMT2A 抗体
: "The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism." in: Oncotarget, Vol. 7, Issue 23, pp. 35341-52, (2016) (PubMed).: "Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells." in: Oncotarget, Vol. 7, Issue 26, pp. 40594-40620, (2016) (PubMed).
: "Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer." in: Biochimica et biophysica acta, Vol. 1849, Issue 6, pp. 697-708, (2015) (PubMed).
: "NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1." in: Nature structural & molecular biology, Vol. 22, Issue 4, pp. 312-8, (2015) (PubMed).
: "Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL." in: Oncogenesis, Vol. 3, pp. e127, (2014) (PubMed).
: "Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins." in: Nucleic acids research, Vol. 42, Issue 14, pp. 9021-32, (2014) (PubMed).
: "RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction." in: Cell reports, Vol. 3, Issue 1, pp. 116-27, (2013) (PubMed).
: "c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis." in: The Journal of clinical investigation, Vol. 120, Issue 2, pp. 593-606, (2010) (PubMed).
: "Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 21, Issue 2, pp. 360-2, (2007) (PubMed).
: "Constitutional duplication 11q23 de novo involving the MLL gene." in: Genetic counseling (Geneva, Switzerland), Vol. 17, Issue 2, pp. 155-9, (2006) (PubMed).
Aliases for MLL/KMT2A 抗体
lysine methyltransferase 2A (KMT2A) 抗体lysine (K)-specific methyltransferase 2A (Kmt2a) 抗体
lysine methyltransferase 2A (Kmt2a) 抗体
6430520K01 抗体
ALL-1 抗体
All1 抗体
CXXC7 抗体
Cxxc7 抗体
HRX 抗体
HTRX1 抗体
mKIAA4050 抗体
MLL 抗体
Mll 抗体
MLL/GAS7 抗体
Mll1 抗体
MLL1A 抗体
TET1-MLL 抗体
TRX1 抗体
WDSTS 抗体
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