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抗Mouse (Murine) SRD5A1 抗体:
抗Human SRD5A1 抗体:
抗Rat (Rattus) SRD5A1 抗体:
Human Polyclonal SRD5A1 Primary Antibody for IHC (p), IHC - ABIN250339
Iczkowski, Qiu, Qian, Somerville, Rittmaster, Andriole, Bostwick: The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. in Urology 2005
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Human Polyclonal SRD5A1 Primary Antibody for WB - ABIN520464
Park, Aizawa, Iemitsu, Sato, Akimoto, Agata, Maeda, Ezawa, Omi: DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats. in Calcified tissue international 2011
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Human Polyclonal SRD5A1 Primary Antibody for IHC, ELISA - ABIN185346
Kapp, Sommer, Kiefer, Dölken, Haendler: 5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis. in Cancer cell international 2012
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Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (显示 AR 抗体) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (显示 DPT 抗体) mice
the Srd5a1 gene modulates ethanol consumption in a sex-dependent manner that is also contingent upon ethanol access condition and concentration
deletion of the Srd5a1 gene significantly decreased ethanol's anxiolytic effect in female mice, and chronic ethanol withdrawal severity was lower in female versus male mice
transcription of srd5a1 in brain is regulated by environmental factor-induced cytosine methylation in the promoter region.
The effects of deficiency or inhibition of S5AR1 on the risk of liver disease and insulin (显示 INS 抗体) resistance in male rats and mice are reported.
Thus, 5alpha-reductase may be required for the estrous cycle variations in affective behavior and 3alpha,5alpha-THP (显示 UMOD 抗体) levels of female mice.
results suggest that local steroid 5 alpha-reductase 1 messenger RNA expression in Withdrawal Seizure-Prone mouse brain may not change in parallel with local allopregnanolone content or withdrawal severity
The aim of the present study was to investigate the role of 5alpha-reductase type 1 for bone mass using Srd5a1-/- mice.
This study evaluates 5alpha-R type I and 3alpha-HSD (显示 DHRS9 抗体) mRNA expression level in mouse brain by using in situ hybridization.
Data suggests that in male mice after social isolation, expression of Srd5a1 mRNA is specifically down-regulated in glutamatergic pyramidal neurons. In socially isolated mice, this down-regulation may account for the appearance of behavioral disorders.
The study described in this article shows that selected SRD5A1 and SRD5A2 (显示 SRD5A2 抗体) polymorphisms can alter the levels of metabolic and hormonal parameters in patients with BPH (显示 GLI3 抗体). Special attention should be paid to the SDR5A2 rs12470143 polymorphism, which is associated with a change in lipid profile, as well as with the inheritance and incidence rate of MetS (显示 ETV3 抗体) among these patients.
Findings suggest that 5alpha-reductases (5-AR) isoenzymes could be explored as a therapeutic target for urothelial bladder cancer (UBC (显示 RPS27A 抗体)) with 5alpha-reductase inhibitors (5-ARI (显示 ARIH1 抗体)).
Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (显示 INS 抗体) resistance (IR) rather than obesity.
Although 4-dione is the main source of 5alpha-dihydrotestosterone in human preadipocytes, production of this steroid by 5 alpha-reductase isoenzymes (SRD5A1, 2 and 3) mediates the inhibitory effect of both 4-dione and testosterone on preadipocyte differentiation.
SRD5A1 small-interfering RNA knockdown led to significant increase in progesterone receptor (显示 PGR 抗体)-B nuclear import, ectopic, whereas SRD5A1 overexpression resulted in remarkable inhibition of nuclear progesterone receptor (显示 PGR 抗体)-B in P4-treated cells. Repression of SRD5A1 activated progesterone receptor (显示 PGR 抗体)-B responsive gene, whereas overexpression of SRD5A1 possessed an inhibitory effect.
the genotypic distribution of 22 single nucleotide polymorphisms in SRD5A1 and SRD5A2 (显示 SRD5A2 抗体) in a set of Spanish prostate cancer patients, were evaluated.
A total of 2 SNPs in SRD5A1-rs3822430 and rs1691053-were associated with prostate-specific antigen level at diagnosis.
In model cell lines of endometrial cancer, AKR1C2 (显示 AKR1C2 抗体) and SRD5A1 have crucial roles in progesterone metabolism.
SRD5A1 rs166050C risk variant was associated with greater prostatic exposure to androsterone
Significantly higher levels of SRD5A1, AKR1C2 (显示 AKR1C2 抗体), AKR1C3 (显示 AKR1C3 抗体), and HSD17B10 (显示 HSD17B10 抗体) mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue
Steroid 5-alpha-reductase (EC 22.214.171.124) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).
, 3-oxo-5-alpha-steroid 4-dehydrogenase 1
, SR type 1
, steroid 5-alpha-reductase 1
, type 1 5alpha-reductase
, 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1
, 5-alpha reductase
, steroid 5-alpha-reductase type I
, steroid 5 alpha-reductase 1
, prostatic steroid 5-alpha-reductase type I
, 3-oxo-5-alpha-steroid 4-dehydrogenase 1-like