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抗Mouse (Murine) POMC 抗体:
抗Human POMC 抗体:
抗Rat (Rattus) POMC 抗体:
Human Polyclonal POMC Primary Antibody for ELISA, IHC - ABIN250413
Mühlhäusler, Adam, Marrocco, Findlay, Roberts, McFarlane, Kauter, McMillen et al.: Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late ... in The Journal of physiology 2005
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Human Polyclonal POMC Primary Antibody for FACS, IF (p) - ABIN673209
Chao, Lu, Lee, Chen, Wang, Yang, Cheng, Liao, Ro: Early systemic granulocyte-colony stimulating factor treatment attenuates neuropathic pain after peripheral nerve injury. in PLoS ONE 2012
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Human Polyclonal POMC Primary Antibody for FACS - ABIN2178604
Xie, Wang, Li, Chao, Yue: Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation. in Neurochemical research 2016
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We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP (显示 AGRP 抗体) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
Data indicate the regulation of energy balance in BMPR1A (显示 BMPR1A 抗体)-mediated appetite regulation in POMC neurons.
POMC and AgRP (显示 AGRP 抗体) neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1 (显示 KISS1 抗体)(ARC (显示 NOL3 抗体)) neurons in male mice
Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.(
disruption of this hippocampal POMC/MC4R (显示 MC4R 抗体) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
These findings indicate that the relevance of AgRP (显示 AGRP 抗体) to POMC neuron GABA connectivity depends on the state of AgRP (显示 AGRP 抗体) neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
these data unmasked a role for mitochondrial fission in leptin (显示 LEP 抗体) sensitivity and glucose sensing of POMC neurons.
it is suggested that the suppression of NeuroD1 (显示 NEUROD1 抗体) expression and the inhibition of NeuroD1 (显示 NEUROD1 抗体)/E-box interaction may play an important role in the Gc-mediated negative regulation of Pomc.
To clarify the functional roles of the AKT-mTOR pathway in the hippocampal neurons, we generated conditional knockout mice harboring the deletion of Pten (Pten-cKO) in Proopiomelanocortin-expressing neurons.
Epo (显示 EPO 抗体) regulates hypothalamus POMC expression via STAT3 (显示 STAT3 抗体) activation.
POMC has played an extraordinary role in the development of molecular endo-crinology and has clearly not yet given up all its secrets.
E2F1 (显示 E2F1 抗体)-mediated hPOMC transcription is a potential target for suppressing ACTH production in ectopic Cushing's syndrome.
Elevated ACTH secretion is associated with Cushing's syndrome.
a novel p53 (显示 TP53 抗体)/POMC/Galphas (显示 GNAS 抗体)/SASH1 (显示 SASH1 抗体) autoregulatory positive feedback loop is regulated by SASH1 (显示 SASH1 抗体) mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (显示 FN1 抗体) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (显示 TNF 抗体), IL-6 (显示 IL6 抗体) and IL-8 (显示 IL8 抗体)) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1 (显示 POU1F1 抗体), SF-1 (显示 NR5A1 抗体), and ACTH.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (显示 MC4R 抗体)), pro-opiomelanocortin (POMC), apolipoprotein E (APOE (显示 APOE 抗体)) and agouti-related protein (AGRP (显示 AGRP 抗体)) with obesity in the North Indian population.
The expression of Pomc mRNA was stimulated in the arcuate nucleus after skin exposure to UVB.
hsa (显示 CD24 抗体)-miR (显示 MLXIP 抗体)-34a can regulate the CRH (显示 CRH 抗体)/CRHR1 (显示 CRHR1 抗体)/POMC axis and may influence body mass index.
these common variants in PCSK1 (显示 PCSK1 抗体) and POMC were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 (显示 PCSK1 抗体) did affect cholesterol level, LDL-C level, and waist circumference.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (显示 PENK 抗体)) and prodynorphin (PDYN (显示 PDYN 抗体)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH (显示 CRH 抗体) and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (显示 GJA1 抗体) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (显示 PHB2 抗体); P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2