Menin 抗体
(Multiple Endocrine Neoplasia 1 (MEN1))
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].
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Latest Publications for our Menin 抗体
: "MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair." in: Molecular and cellular biology, Vol. 33, Issue 13, pp. 2635-47, (2013) (PubMed).: "Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation." in: Glia, Vol. 60, Issue 9, pp. 1427-36, (2012) (PubMed).
: "Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors." in: PLoS ONE, Vol. 7, Issue 5, pp. e37952, (2012) (PubMed).
: "The negative feedback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the "Knudson's second hit"." in: PLoS ONE, Vol. 7, Issue 6, pp. e39767, (2012) (PubMed).
: "Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 303, Issue 6, pp. G752-64, (2012) (PubMed).
: "Tumor suppressor menin mediates peripheral nerve injury-induced neuropathic pain through potentiating synaptic plasticity." in: Neuroscience, Vol. 223, pp. 473-85, (2012) (PubMed).
: "Insulin regulates menin expression, cytoplasmic localization, and interaction with FOXO1." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 3, pp. E474-83, (2011) (PubMed).
: "Regulation of cyclin B2 expression and cell cycle G2/m transition by menin." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18291-300, (2010) (PubMed).
: "Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice." in: Endocrinology, Vol. 151, Issue 8, pp. 4024-30, (2010) (PubMed).
: "MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases." in: Endocrine-related cancer, Vol. 17, Issue 3, pp. 771-83, (2010) (PubMed).
Aliases for Menin 抗体
menin 1 (MEN1) 抗体menin 1 (men1) 抗体
menin 1 L homeolog (men1.L) 抗体
multiple endocrine neoplasia I (men1) 抗体
multiple endocrine neoplasia 1 (Men1) 抗体
menin 1 (Men1) 抗体
AW045611 抗体
MEAI 抗体
meai 抗体
menin 抗体
SCG2 抗体
scg2 抗体
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