MCM2 抗体
(Minichromosome Maintenance Complex Component 2 (MCM2))
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012].
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Latest Publications for our MCM2 抗体
: "Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 32, pp. E3325-34, (2014) (PubMed).: "A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication." in: Science signaling, Vol. 6, Issue 262, pp. ra10, (2013) (PubMed).
: "Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer." in: The Prostate, Vol. 72, Issue 14, pp. 1491-505, (2012) (PubMed).
: "Matrix-embedded endothelial cells are protected from the uremic milieu." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 26, Issue 12, pp. 3858-65, (2011) (PubMed).
: "A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 6, pp. 1490-501, (2011) (PubMed).
: "Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA." in: Nucleic acids research, Vol. 39, Issue 12, pp. 5057-66, (2011) (PubMed).
: "Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition." in: The Journal of biological chemistry, Vol. 286, Issue 26, pp. 23031-43, (2011) (PubMed).
: "HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression." in: Cancer research, Vol. 71, Issue 17, pp. 5621-5, (2011) (PubMed).
: "MCM proteins are negative regulators of hypoxia-inducible factor 1." in: Molecular cell, Vol. 42, Issue 5, pp. 700-12, (2011) (PubMed).
: "Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers." in: The American journal of pathology, Vol. 177, Issue 4, pp. 2034-45, (2010) (PubMed).
Aliases for MCM2 抗体
Minichromosome maintenance 2 (Mcm2) 抗体minichromosome maintenance complex component 2 (mcm2) 抗体
minichromosome maintenance complex component 2 (MCM2) 抗体
minichromosome maintenance complex component 2 (Mcm2) 抗体
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