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抗Human BCL2 抗体:
抗Rat (Rattus) BCL2 抗体:
抗Mouse (Murine) BCL2 抗体:
Human Monoclonal BCL2 Primary Antibody for ICC, IHC (fro) - ABIN3044481
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
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Human Polyclonal BCL2 Primary Antibody for ELISA, WB - ABIN3042814
Zong, Li, Lin, Hou, Ma: Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats. in American journal of translational research 2017
Show all 79 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IF, IHC (p) - ABIN388095
Zheng, Zhou, Ye, Li, Bai, Zhang: The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. in World journal of surgical oncology 2010
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Human Polyclonal BCL2 Primary Antibody for IF (p), IHC (p) - ABIN707156
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. in Biological trace element research 2013
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Dog (Canine) Polyclonal BCL2 Primary Antibody for IHC, IHC (p) - ABIN4283360
Chopra, Ray, Dwivedi, Tiwari, Singh, Singh, Kushwaha, Jahan, Pandey, Gupta, Chaturvedi, Pant, Ray, Gupta: Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. in Biomaterials 2016
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Human Monoclonal BCL2 Primary Antibody for IP, IHC - ABIN222984
Cordiali-Fei, Ardigo, Mastroianni, Giuliani, D Agosto, Bordignon, Trento, Vento, Berardesca: Serum cytokines and biohumoral immunological characterization of psoriatic patients in long term etanercept treatment. in International journal of immunopathology and pharmacology 2008
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Human Monoclonal BCL2 Primary Antibody for ICS - ABIN1177234
Deng, Xiao, Lang, Gao, Ruvolo, May: Novel role for JNK as a stress-activated Bcl2 kinase. in The Journal of biological chemistry 2001
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Human Monoclonal BCL2 Primary Antibody for ICS - ABIN1177233
Maundrell, Antonsson, Magnenat, Camps, Muda, Chabert, Gillieron, Boschert, Vial-Knecht, Martinou, Arkinstall: Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. in The Journal of biological chemistry 1997
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Human Monoclonal BCL2 Primary Antibody for FACS, ICC - ABIN638444
Soilu-Hänninen, Ekert, Bucci, Syroid, Bartlett, Kilpatrick: Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
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Human Polyclonal BCL2 Primary Antibody for ELISA, WB - ABIN268671
Pachori, Melo, Zhang, Solomon, Dzau: Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery. in Journal of the American College of Cardiology 2006
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Permeabilisation of the mitochondrial outer membrane (MOMP) is directly regulated by the BCL-2 (B cell lymphoma 2) family in mammals [Review].
These results suggest that chlorogenic acid (CGA (显示 CGA 抗体))suppresses hLECs apoptosis and prevents lens opacity (显示 MIP 抗体) induced by H2O2 via Bax (显示 BAX 抗体)/Bcl2 signaling pathway. CGA (显示 CGA 抗体) may provide effective defenses against oxidative stress and, thus, has potential as treatment for a variety of diseases in clinical practice.
The present study demonstrated that TATfused inositol 1,4,5trisphosphate receptorderived peptide (TATIDPS), which targets the BH4 domain of Bcl2, increased cisplatininduced Ca2 (显示 CA2 抗体)+ flux from the endoplasmic reticulum (ER) into the cytosol and mitochondria.
we highlight the emerging recognition of MYC (显示 MYC 抗体) and BCL2 coexpression as the most robust predictor of diffuse large B cell lymphoma outcome, and discuss rationally conceived experimental approaches to treat these high-risk patients.
Bcl-2 binding to ARTS involves the BH3 domain of Bcl-2. Lysine 17 in Bcl-2 serves as the main acceptor for ubiquitylation, and a Bcl-2 K17A mutant has increased stability and is more potent in protection against apoptosis.
The expression levels of miR (显示 MLXIP 抗体)-204-5p were downregulated in prostate cancer cells compared with normal prostate epithelial cells. BCL2 mRNA and protein expression decreased in miR (显示 MLXIP 抗体)-204-5p-transfected cells, which led to cytochrome C (显示 CYCS 抗体) release from mitochondria. Cotransfection of a reporter vector harboring the BCL2 3'-untranslated region to compete with endogenous transcripts partially rescued miR (显示 MLXIP 抗体)-204-5p-induced apoptosis.
GATA4 (显示 GATA4 抗体) was a transcription factor that activated mouse double minute 2 homolog (MDM2 (显示 MDM2 抗体)) and B cell lymphoma 2 (BCL2) expression in ALL cells.
High BCL2 expression is associated with oncogenicity and chemoresistance in hepatocellular carcinoma.
Gastrin (显示 GAST 抗体) and BCL2 apoptosis regulator (Bcl2) are highly expressed in gastric cancer tissues, and they are correlated with the clinicopathologic features.
This study utilized a lentiviral vector that overexpressed the human VEGF (显示 VEGFA 抗体) and Bcl-2 genes simultaneously. Co-overexpression of VEGF (显示 VEGFA 抗体) and Bcl-2 inhibits the oxygen glucose deprivation induced apoptosis of mesenchymal stem cells.
MiR (显示 MLXIP 抗体)-146a inhibits proliferation and induces apoptosis in murine osteoblastic MC3T3-E1 by regulating Bcl2
The data revealed that autophagy is an important regulator of osteoblastic apoptosis through its interaction with Bax (显示 BAX 抗体)/Bcl2, and maintains the osteoblastic function of MC3T3E1 cells following GC exposure. In addition, these results indicated that the suppression of autophagy in OBs (显示 LEP 抗体) under chronic GC therapy may increase the prevalence of GCinduced osteoporosis and fragility fractures.
Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53 (显示 TP53 抗体)/Bax (显示 BAX 抗体) activation.
The results suggest that SPK2 (显示 SPHK2 抗体) interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 (显示 BECN1 抗体) and activating autophagy while protecting neurons against ischemic injury.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1 (显示 MCL1 抗体), and BCL2A1 (显示 BCL2A1 抗体), rather than by a single anti-apoptotic protein.
Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.
Bcl2 is the autophagy-related target of miR (显示 MLXIP 抗体)-449a.
anti-apoptotic molecules BclxL (显示 BCL2L1 抗体) and Bcl-2 and the pro-apoptotic factors BAD and BID (显示 BID 抗体) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (显示 FASL 抗体).
Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS (显示 ROS1 抗体)-JNK (显示 MAPK8 抗体)-Bcl-2 signaling pathway.
Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.
These results suggest a role for mitochondrial p53 (显示 TP53 抗体) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (显示 BAX 抗体) and Bcl2.
Zebrafish gene expressions of P53 (显示 TP53 抗体), Bcl-2, Bax (显示 BAX 抗体) and caspase-3 (显示 CASP3 抗体) were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (显示 S1PR1 抗体), and ICAM1 (显示 ICAM1 抗体) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 (显示 COX2 抗体) and bcl2, but increased p53 (显示 TP53 抗体) expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (显示 NOTCH1 抗体) and fish bcl-2, indicating synergy between the Notch (显示 NOTCH1 抗体) pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 (显示 STC1 抗体) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (显示 CASP3 抗体) production in the damaged cells. Findings from this study suggest that STC-1 (显示 STC1 抗体) plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (显示 BAX 抗体) expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 (显示 FLT1 抗体) in Bcl-2 expression
apoptosis-inducing factor (显示 AIFM1 抗体) was expressed in luminal alveolar cells and, in concert with a change in bax (显示 BAX 抗体) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax (显示 BAX 抗体), Bcl-2, caspase-3 (显示 CASP3 抗体) and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax (显示 BAX 抗体) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (显示 BAX 抗体)]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (显示 CASP3 抗体) expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax (显示 BAX 抗体) ratio through a mechanism involving protein kinase C (显示 PKC 抗体).
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (显示 BAX 抗体) and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (显示 BAX 抗体).
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (显示 TP53 抗体) and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (显示 CASP3 抗体).
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2
, LOW QUALITY PROTEIN: apoptosis regulator Bcl-2
, Apoptosis regulator Bcl-2