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抗Human BCL2 抗体:
抗Rat (Rattus) BCL2 抗体:
抗Mouse (Murine) BCL2 抗体:
Human Monoclonal BCL2 Primary Antibody for ICC, IHC (fro) - ABIN3044481
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
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Human Polyclonal BCL2 Primary Antibody for ELISA, WB - ABIN3042814
Zong, Li, Lin, Hou, Ma: Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats. in American journal of translational research 2017
Show all 137 Pubmed References
Human Polyclonal BCL2 Primary Antibody for WB - ABIN5518894
Xu, Yu, He, Li, Yu, Yu: Effects of garlicin on apoptosis in rat model of colitis. in World journal of gastroenterology 2005
Show all 87 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, IHC - ABIN5693065
Bentley: Primary health care in northwestern Somalia: a case study. in Social science & medicine (1982) 1989
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Human Polyclonal BCL2 Primary Antibody for IF, IHC (p) - ABIN388095
Zheng, Zhou, Ye, Li, Bai, Zhang: The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. in World journal of surgical oncology 2010
Show all 23 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, ICC - ABIN6260222
Zhang, Chen, Wang, Yang, Li, Wang, Liu, Ye: Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. in Oncotarget 2018
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Human Polyclonal BCL2 Primary Antibody for IF (p), IHC (p) - ABIN707156
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. in Biological trace element research 2013
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Dog (Canine) Polyclonal BCL2 Primary Antibody for IHC, IHC (p) - ABIN4283360
Chopra, Ray, Dwivedi, Tiwari, Singh, Singh, Kushwaha, Jahan, Pandey, Gupta, Chaturvedi, Pant, Ray, Gupta: Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. in Biomaterials 2016
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Human Monoclonal BCL2 Primary Antibody for ICS - ABIN1177233
Maundrell, Antonsson, Magnenat, Camps, Muda, Chabert, Gillieron, Boschert, Vial-Knecht, Martinou, Arkinstall: Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. in The Journal of biological chemistry 1997
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Human Monoclonal BCL2 Primary Antibody for ICS - ABIN1177234
Deng, Xiao, Lang, Gao, Ruvolo, May: Novel role for JNK as a stress-activated Bcl2 kinase. in The Journal of biological chemistry 2001
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Rab14 was overexpressed in pancreatic cancer and promotes growth and gemcitabine resistance, possibly through regulation of mitochondrial function and Bcl-2.
Data provide evidences supporting the role of Sema5A in melanoma progression and the involvement of Bcl-2, miR-204 and c-Myb in regulating its expression.
BCL6 translocation was detected in 15 (12%) cases. Translocation involving MYC and BCL2 was identified in 3 cases (3.8%) and 1 case (1.3%) respectively. One double hit lymphoma was discovered with both MYC/BCL2 translocation (1.3%).
the findings of the present study revealed a novel mechanism of estrogendependent apoptotic suppression of Endometriosis (EMS)associated with TSLP secretion and Bcl2 regulation. Endogenous and estrogeninduced endometrial TSLP may promote the initiation and development of EMS via the inhibition of apoptosis
BCL2, CCND1 and COL1A1 may be key novel clinically relevant genes in papillary thyroid carcinoma.
long noncoding RNA HOTAIR suppresses TNF-alpha induced nucleus pulposus cell apoptosis by regulating miR-34a/Bcl-2 axis.
The mitochondrial depolarization also stems from the Bcl-2 inhibition mediated by DFMT, followed by the cytochrome c release that activates caspase signaling. With the participation of the two-pronged mechanism, a programmed apoptosis is induced in response to DFMT treatment.
miR-7-5p reduced energy consumption via inhibiting PARP-1 expression, and miR-7-5p increased energy generation by suppressing the expression of Bcl-2.
Venetoclax-based combination treatment for newly diagnosed elderly patients for whom intense chemotherapy is not an option may be the first setting in which this agent may be employed in Acute myeloid leukemia. Based on pre-clinical evidence, BCL-2 inhibition may be useful in relapsed/refractory disease in conjunction with cytotoxic therapy, but has modest single agent activity.
Glandular, menopause-independent DFF40, DFF45, and Bcl-2 overexpression may play an important role in the pathogenesis of endometrial polyps and benign endometrial hyperplasia
data strongly suggest that XIAP-mediated inhibition of final caspase-3 processing is the last and major hurdle in TRAIL-induced apoptosis in NCI-H460 cells, which can be overcome by Smac in a Bcl-2 level dependent manner.
could not find any relationship between Bcl-2, c-Myc and EBER-ISH positivity and the low/high IPS groups in classical Hodgkin lymphoma
Fluorescence in situ hybridization studies (histologic sections) confirmed translocations of MYC (8q24), BCL2 (18q21) and BCL6 (3q27) in all patients.
High BCL-2 expression is associated with colorectal cancer.
MiR-29a down-regulation is correlated with drug resistance of nasopharyngeal carcinoma cell line CNE-1 and MiR-29a up-regulation decreases Taxol resistance of nasopharyngeal carcinoma CNE-1 cells possibly via inhibiting STAT3 and Bcl-2 expression.
Results revealed that BCL-2 protein is highly expressed in colon cancer tissues and was identified as a direct target for mir-184. BCL-2 appeared to participate in cell cycle regulation and malignant transformation to colon cancer.
Results indicate that full-length B-cell leukemia 2 family protein (Bcl-2) Ile14Gly/Val15Gly displayed severely reduced structural stability and a shortened protein half-life.
Data show the regulation of BCL2 mainly associated with methylation across the molecular subtypes of breast cancer. Luminal A and B subtypes showed upregulated expression of BCL2 protein, mRNA, and hypomethylation. Although copy number alteration may have played a minor role, mutation status was not related to BCL2 regulation. Upregulation of BCL2 was associated with better prognosis than downregulation of BCL2.
The results of the present study revealed that the combination of P. gingivalis and H1N1 infection in lung epithelial cells may promote the production of inflammatory cytokines and increase NO production, leading to increased levels of apoptosis in lung epithelial cells via the Bcl2/Bax/caspase3 signaling pathway.
Authors found that the phenotypic alterations by miR-365 were partially due to downregulation of CCND1 and BCL2 oncogenes.
data demonstrate that disruption of the beclin 1-BCL2 complex is an effective mechanism to increase autophagy, prevent premature ageing, improve healthspan and promote longevity in mammals
Results support a link between age-related apoptosis in auditory cortex neurons and miR-34a/Bcl-2 signaling, which may serve as a potential mechanism of the expression of age-related hearing loss in the auditory cortex.
MiR-146a inhibits proliferation and induces apoptosis in murine osteoblastic MC3T3-E1 by regulating Bcl2
The data revealed that autophagy is an important regulator of osteoblastic apoptosis through its interaction with Bax/Bcl2, and maintains the osteoblastic function of MC3T3E1 cells following GC exposure. In addition, these results indicated that the suppression of autophagy in OBs under chronic GC therapy may increase the prevalence of GCinduced osteoporosis and fragility fractures.
Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation.
The results suggest that SPK2 interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 and activating autophagy while protecting neurons against ischemic injury.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1, and BCL2A1, rather than by a single anti-apoptotic protein.
Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.
Bcl2 is the autophagy-related target of miR-449a.
anti-apoptotic molecules BclxL and Bcl-2 and the pro-apoptotic factors BAD and BID cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L.
Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS-JNK-Bcl-2 signaling pathway.
Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.
E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 and FoxO transcription factors and then their target genes Bcl-2, Bim, Puma, PERP, and MDM2, without affecting Noxa gene.
Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure
The results suggest that CARP can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
This study provides evidence from transgenic mouse models that Crebbp deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma.
an essential role for the binding of BCL2 to BIM in the survival of noncycling NK cells.
LIGHT signalling pathway combined with IFN-gamma induces beta cells apoptosis via an NF-kappaB/Bcl2-dependent mitochondrial pathway.
Bcl-2 was highly expressed in tubulointerstitial infiltrates in (NZB x NZW)F1 (NZB/NZW) lupus-prone mice.
Bcell lymphoma 2, an antiapoptotic gene, was the target of mmumiR96.
upregulated in choriodecidua following labor
These results suggest a role for mitochondrial p53 activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2.
Zebrafish gene expressions of P53, Bcl-2, Bax and caspase-3 were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1, and ICAM1 in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 and fish bcl-2, indicating synergy between the Notch pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 in Bcl-2 expression
apoptosis-inducing factor was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax, Bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax.
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3.
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2
, LOW QUALITY PROTEIN: apoptosis regulator Bcl-2
, Apoptosis regulator Bcl-2