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抗Human BCL2 抗体:
抗Rat (Rattus) BCL2 抗体:
抗Mouse (Murine) BCL2 抗体:
Human Monoclonal BCL2 Primary Antibody for ICC, IHC (fro) - ABIN3044481
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
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Human Polyclonal BCL2 Primary Antibody for ELISA, WB - ABIN3042814
Zong, Li, Lin, Hou, Ma: Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats. in American journal of translational research 2017
Show all 137 Pubmed References
Human Polyclonal BCL2 Primary Antibody for WB - ABIN5518894
Xu, Yu, He, Li, Yu, Yu: Effects of garlicin on apoptosis in rat model of colitis. in World journal of gastroenterology 2005
Show all 87 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, IHC - ABIN5693065
Bentley: Primary health care in northwestern Somalia: a case study. in Social science & medicine (1982) 1989
Show all 82 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IF, IHC (p) - ABIN388095
Zheng, Zhou, Ye, Li, Bai, Zhang: The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. in World journal of surgical oncology 2010
Show all 23 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, ICC - ABIN6260222
Zhang, Chen, Wang, Yang, Li, Wang, Liu, Ye: Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. in Oncotarget 2018
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Human Polyclonal BCL2 Primary Antibody for IF (p), IHC (p) - ABIN707156
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. in Biological trace element research 2013
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Dog (Canine) Polyclonal BCL2 Primary Antibody for IHC, IHC (p) - ABIN4283360
Chopra, Ray, Dwivedi, Tiwari, Singh, Singh, Kushwaha, Jahan, Pandey, Gupta, Chaturvedi, Pant, Ray, Gupta: Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. in Biomaterials 2016
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Human Monoclonal BCL2 Primary Antibody for ICS - ABIN1177234
Deng, Xiao, Lang, Gao, Ruvolo, May: Novel role for JNK as a stress-activated Bcl2 kinase. in The Journal of biological chemistry 2001
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Human Monoclonal BCL2 Primary Antibody for ICS - ABIN1177233
Maundrell, Antonsson, Magnenat, Camps, Muda, Chabert, Gillieron, Boschert, Vial-Knecht, Martinou, Arkinstall: Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. in The Journal of biological chemistry 1997
Show all 5 Pubmed References
High BCL-2 expression is associated with colorectal cancer.
MiR (显示 MLXIP 抗体)-29a down-regulation is correlated with drug resistance of nasopharyngeal carcinoma cell line CNE-1 and MiR (显示 MLXIP 抗体)-29a up-regulation decreases Taxol resistance of nasopharyngeal carcinoma CNE-1 cells possibly via inhibiting STAT3 (显示 STAT3 抗体) and Bcl-2 expression.
Results revealed that BCL-2 protein is highly expressed in colon cancer tissues and was identified as a direct target for mir (显示 MLXIP 抗体)-184. BCL-2 appeared to participate in cell cycle regulation and malignant transformation to colon cancer.
Results indicate that full-length B-cell leukemia 2 family protein (Bcl-2) Ile14Gly/Val15Gly displayed severely reduced structural stability and a shortened protein half-life.
Data show the regulation of BCL2 mainly associated with methylation across the molecular subtypes of breast cancer. Luminal A and B subtypes showed upregulated expression of BCL2 protein, mRNA, and hypomethylation. Although copy number alteration may have played a minor role, mutation status was not related to BCL2 regulation. Upregulation of BCL2 was associated with better prognosis than downregulation of BCL2.
The results of the present study revealed that the combination of P. gingivalis and H1N1 infection in lung epithelial cells may promote the production of inflammatory cytokines and increase NO production, leading to increased levels of apoptosis in lung epithelial cells via the Bcl2/Bax (显示 BAX 抗体)/caspase3 signaling pathway.
Authors found that the phenotypic alterations by miR (显示 MLXIP 抗体)-365 were partially due to downregulation of CCND1 (显示 CCND1 抗体) and BCL2 oncogenes.
c-MYC (显示 MYC 抗体)/BCL2 protein co-expression in non-germinal center B-cell subtype constituted a unique group with extremely inferior outcome regardless of ethnicity
Overexpression of LIN28B (显示 LIN28B 抗体) promotes colon cancer development by increasing BCL-2 expression.
High BCL2 expression is associated with Prostate Cancer.
data demonstrate that disruption of the beclin 1 (显示 BECN1 抗体)-BCL2 complex is an effective mechanism to increase autophagy, prevent premature ageing, improve healthspan and promote longevity in mammals
Results support a link between age-related apoptosis in auditory cortex neurons and miR (显示 MLXIP 抗体)-34a/Bcl-2 signaling, which may serve as a potential mechanism of the expression of age-related hearing loss in the auditory cortex.
MiR (显示 MLXIP 抗体)-146a inhibits proliferation and induces apoptosis in murine osteoblastic MC3T3-E1 by regulating Bcl2
The data revealed that autophagy is an important regulator of osteoblastic apoptosis through its interaction with Bax (显示 BAX 抗体)/Bcl2, and maintains the osteoblastic function of MC3T3E1 cells following GC exposure. In addition, these results indicated that the suppression of autophagy in OBs (显示 LEP 抗体) under chronic GC therapy may increase the prevalence of GCinduced osteoporosis and fragility fractures.
Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53 (显示 TP53 抗体)/Bax (显示 BAX 抗体) activation.
The results suggest that SPK2 (显示 SPHK2 抗体) interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 (显示 BECN1 抗体) and activating autophagy while protecting neurons against ischemic injury.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1 (显示 MCL1 抗体), and BCL2A1 (显示 BCL2A1 抗体), rather than by a single anti-apoptotic protein.
Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.
Bcl2 is the autophagy-related target of miR (显示 MLXIP 抗体)-449a.
anti-apoptotic molecules BclxL (显示 BCL2L1 抗体) and Bcl-2 and the pro-apoptotic factors BAD and BID (显示 BID 抗体) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (显示 FASL 抗体).
These results suggest a role for mitochondrial p53 (显示 TP53 抗体) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (显示 BAX 抗体) and Bcl2.
Zebrafish gene expressions of P53 (显示 TP53 抗体), Bcl-2, Bax (显示 BAX 抗体) and caspase-3 (显示 CASP3 抗体) were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (显示 S1PR1 抗体), and ICAM1 (显示 ICAM1 抗体) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 (显示 COX2 抗体) and bcl2, but increased p53 (显示 TP53 抗体) expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (显示 NOTCH1 抗体) and fish bcl-2, indicating synergy between the Notch (显示 NOTCH1 抗体) pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 (显示 STC1 抗体) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (显示 CASP3 抗体) production in the damaged cells. Findings from this study suggest that STC-1 (显示 STC1 抗体) plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (显示 BAX 抗体) expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 (显示 FLT1 抗体) in Bcl-2 expression
apoptosis-inducing factor (显示 AIFM1 抗体) was expressed in luminal alveolar cells and, in concert with a change in bax (显示 BAX 抗体) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax (显示 BAX 抗体), Bcl-2, caspase-3 (显示 CASP3 抗体) and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax (显示 BAX 抗体) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (显示 BAX 抗体)]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (显示 CASP3 抗体) expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (显示 BAX 抗体) and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (显示 BAX 抗体).
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (显示 TP53 抗体) and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (显示 CASP3 抗体).
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2
, LOW QUALITY PROTEIN: apoptosis regulator Bcl-2
, Apoptosis regulator Bcl-2