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抗Human ARAF 抗体:
抗Mouse (Murine) ARAF 抗体:
抗Rat (Rattus) ARAF 抗体:
different isoforms of Araf may participate in similar developmental processes but by regulating different signaling pathways
The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2 (显示 STK3 抗体), thus rendering cells susceptible to apoptosis
This review discusses the regulation of A-Raf protein (显示 RAF1 抗体) expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf (显示 RAF1 抗体) inhibitors. [review]
analysis of FGFR2 (显示 FGFR2 抗体)-PPHLN1 (显示 PPHLN1 抗体) fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Aberrant expression of A-, B-, and C-RAF (显示 RAF1 抗体), and COT (显示 MAP3K8 抗体) is frequent in PTC (显示 F9 抗体); increased expression of COT (显示 MAP3K8 抗体) is correlated with recurrence of PTC (显示 F9 抗体).
Dimerization of the kinase ARAF promotes MAPK (显示 MAPK1 抗体) pathway activation and cell migration.
The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis.
Galpha12 (显示 GNA12 抗体)-ARAF-ERK (显示 EPHB2 抗体) pathway stimulates RFFL (显示 RFFL 抗体) transcription through the transcription factor c-Myc (显示 MYC 抗体).
show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 (显示 SMAD2 抗体) signals in vertebrate embryos by directly inhibiting Smad2 (显示 SMAD2 抗体) signalling
study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK (显示 MAPK1 抗体) pathway in cells treated with RAF (显示 RAF1 抗体) inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF (显示 RAF1 抗体) inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency
Ras pathway activation via EGF (显示 EGF 抗体) treatment induced strong binding between B-Raf (显示 SNRPE 抗体) and C-Raf (显示 RAF1 抗体) and a low level of binding between B-Raf (显示 SNRPE 抗体) and A-Raf.
PKM1 interacts with A-Raf, an upstream regulator of the MEK (显示 MDK 抗体)/ERK (显示 EPHB2 抗体) pathway, and that this interaction contributes to MEK1 (显示 MAP2K1 抗体) phosphorylation by A-Raf.
A- and B-Raf (显示 SNRPE 抗体) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf (显示 RAF1 抗体) decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf (显示 RAF1 抗体) does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (显示 VEGFA 抗体) protein stability.
A-Raf promotes osteoblasts differentiation in response to mechanical stress.
DA-Raf (显示 RAF1 抗体)-dependent inhibition of the Ras-ERK (显示 EPHB2 抗体) signaling pathway in alveolar epithelial 2 cells is required for alveolar formation via triggering MMP2 (显示 MMP2 抗体) activation followed by myofibroblast differentiation.
Expression of Araf in the mouse nucleus accumbens is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (显示 UTS2R 抗体) of Comt (catechol-O-methyltransferase (显示 COMT 抗体)).
the binding of 14-3-3gamma to Raf (显示 RAF1 抗体) indicates the critical role of this protein in ischemia-induced apoptosis and the changes in signal transduction in astrocytes in culture.
Raf-1 (显示 RAF1 抗体) and A-Raf have a combined role in controlling physiological transient ERK (显示 EPHB2 抗体) activation and in maintenance of cell cycle progression at its usual rate.
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
serine/threonine protein kinase ARAF standard form
, serine/threonine-protein kinase A-Raf
, v-raf murine sarcoma 3611 viral oncogene homolog
, v-raf murine sarcoma 3611 viral oncogene-like protein
, serine/threonine protein kinase ARAF
, serine/threonine-protein kinase A-Raf-like
, A-Raf proto-oncogene serine/threonine-protein kinase
, Oncogene ARAF1
, Ras-binding protein DA-Raf
, proto-oncogene A-Raf-1
, proto-oncogene Pks
, v-raf murine sarcoma 3611 viral oncogene homolog 1
, proto-oncogene A-Raf
, raf-related oncogene
, Raf related protein
, Ras-binding protein
, v-raf oncogene homolog 1 (murine sarcoma 3611 virus)