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抗Mouse (Murine) Caveolin-1 抗体:
抗Rat (Rattus) Caveolin-1 抗体:
抗Human Caveolin-1 抗体:
Human Monoclonal Caveolin-1 Primary Antibody for FACS, ICC - ABIN152046
Souto, Vallega, Wharton, Vinten, Tranum-Jensen, Pilch: Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. in The Journal of biological chemistry 2003
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Human Polyclonal Caveolin-1 Primary Antibody for WB - ABIN2801935
Glenney: The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. in FEBS letters 1992
Show all 4 Pubmed References
Human Polyclonal Caveolin-1 Primary Antibody for IHC - ABIN965753
Maggi, Biedi, Segat, Barbero, Panetta, Cordera: IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts. in Biochemical and biophysical research communications 2002
Show all 4 Pubmed References
Rat (Rattus) Monoclonal Caveolin-1 Primary Antibody for WB - ABIN2192105
Salani, Passalacqua, Maffioli, Briatore, Hamoudane, Contini, Cordera, Maggi: IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. in PLoS ONE 2010
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Human Caveolin-1 Primary Antibody for IHC - ABIN965752
Zhang, Wolf-Yadlin, Ross, Pappin, Rush, Lauffenburger, White: Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. in Molecular & cellular proteomics : MCP 2005
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Dog (Canine) Polyclonal Caveolin-1 Primary Antibody for ELISA, WB - ABIN2477937
Shah, Bhatt, Patel: Use of photoresistor for the measurement of light absorption in cytophotometer. in Indian journal of experimental biology 1976
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Dog (Canine) Polyclonal Caveolin-1 Primary Antibody for FACS, ICC - ABIN152668
Li, Liu, Pilcher, Anderson: Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria. in Journal of cell science 2001
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Great Pond Snail (Lymnaea stagnalis) Polyclonal Caveolin-1 Primary Antibody for IHC - ABIN965751
Spafford, Munno, Van Nierop, Feng, Jarvis, Gallin, Smit, Zamponi, Syed: Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons. in The Journal of biological chemistry 2003
Human Polyclonal Caveolin-1 Primary Antibody for FACS, IF (p) - ABIN686752
Cheng, Song, Li, Zhao, An, Sun, Luo: The role of rosiglitazone in the proliferation of vascular smooth muscle cells after experimental subarachnoid hemorrhage. in Acta neurochirurgica 2014
Human Polyclonal Caveolin-1 Primary Antibody for IF, WB - ABIN362044
Fielding, Chau, Liu, Spencer, Fielding: Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80. in Biochemistry 2004
Show all 6 Pubmed References
These results point to intestinal epithelial cell CAV1 as a potential therapeutic target to lower circulating free fatty acids and LDL cholesterol.
Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
The development of transgenic zebrafish lines expressing CLTA (显示 CLTA 抗体) fused to dsRed and CAV1 fused to GFP is reported.
maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin (显示 CTNNB1 抗体)
These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis.
interactions of cav1 at lipid-exposed domains regulate the partition of the receptor into membrane raft microdomains
the present study indicated that Cav-1-/- accelerated liver injury in a mouse model of liver fibrosis through enhancing oxidative stress, inflammatory response and fibrosis progression
MURC (显示 MURC 抗体) binds to Cav1 and inhibits the association of Cav1 with the active form of Galpha13 (显示 GNA13 抗体), resulting in the facilitated association of the active form of Galpha13 (显示 GNA13 抗体) with p115RhoGEF (显示 ARHGEF1 抗体). These results reveal that MURC (显示 MURC 抗体) has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling.
The part of PKC regulation of CaV1.2 in the heart involves changes in channel's cellular fate. The mechanism of this PKC regulation appears to involve the C-terminus of alpha1C, possibly corroborating the previously proposed role of NT-CT interactions within alpha1C.
Findings suggest that CAV1 might be involved in apoptosis and proliferation regulation in pancreatic beta cells.
Caveolin1 is required for Th1 (显示 HAND1 抗体) cell infiltration, but not tight junction remodeling at the Blood-Brain Barrier in autoimmune neuroinflammation
Results suggest distinct functional roles for type 1 ryanodine receptor (RYR1 (显示 RYR1 抗体)) and Ca2 (显示 CA2 抗体)+ channels-the 1,4-dihydropyridine receptor (Cav1.1 (显示 CACNA1S 抗体)) in skeletal primary and secondary myogenesis.
genetic deletion of Cav-1 exacerbated and cavtratin administration inhibited choroidal and retinal neovascularization
findings suggest that HMGB1 (显示 HMGB1 抗体) induces the transcytosis of albumin (显示 ALB 抗体) via RAGE (显示 AGER 抗体)-dependent Src (显示 SRC 抗体) phosphorylation and Cav-1 phosphorylation. These studies revealed a new mechanism of HMGB1 (显示 HMGB1 抗体)-induced endothelial hyperpermeability.
caveolin-1 (Cav-1) participates in intraocular pressure maintenance via modulation of aqueous humor drainage from the eye.
DJ-1 (显示 PARK7 抗体) has a role in glutamate (显示 GRIN1 抗体) uptake into astrocytes by regulating flotillin-1 (显示 FLOT1 抗体) and caveolin-1 expression
CAV-1 is important for NAFLD (显示 TSC2 抗体)-HCC (显示 FAM126A 抗体) survival in fatty acid-rich environments and is a potential therapeutic target.
At the onset of mitotic cell rounding, caveolin-1 is targeted to the retracting cortical region at the proximal end of retraction fibres, where ganglioside GM1-enriched membrane domains with clusters of caveola-like structures are formed in an integrin and RhoA (显示 RHOA 抗体)-dependent manner.
down-regulation of Cav-1 may aggravate DNA damage of Chang liver cells through reducing the interaction of Cav-1 and Mdm2 (显示 MDM2 抗体), which results in the promotion of p53 (显示 TP53 抗体) degradation.
High CAV1 expression is associated with Small Cell Lung Cancer.
NEDD8 (显示 NEDD8 抗体) seems to inhibit the Src (显示 SRC 抗体)-mediated phosphorylation of caveolin-1 by modifying the structure of caveolin-1 protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.
High CAV1 expression is associated with Aggressive Behaviour of Breast Cancer.
Cav1 and PY14Cav1 were positively correlated with ESCC lymphatic metastasis and cancer stages. Rho/ROCK pathway activation promoted ESCC metastasis by regulating Cav1.
we revisited the question of the relationship between Cav1 and Stat3 (显示 STAT3 抗体)-ptyr705 in non-transformed mouse fibroblasts and in human lung carcinoma cells, by examining their effect at different cell densities.Our results demonstrate that Cav1 downregulates cadherin-11, by a mechanism which requires the Cav1 scaffolding domain. This cadherin-11 downregulation, leads to a reduction in cRac1 and Stat3 (显示 STAT3 抗体) activity levels.
Cav-1 acts as a positive or negative regulator of tumor cell growth via the reciprocal control for the RAF (显示 RAF1 抗体)-ERK (显示 EPHB2 抗体) feedback loop, and the mitogenic switch of Cav-1 function is tightly linked to bidirectional alteration of its expression in tumor progression.
This is the first demonstration of caveolin-1 expression in human primary uveal melanoma cell lines and observation that the origin of cells (uveal/cutaneous) has an impact when considering the utility of caveolin-I as a melanoma cell marker.
Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer
transcription factor Sp1 (显示 SP1 抗体) interacts with nucleotides -123/-114, indicating that Sp1 (显示 SP1 抗体) could play a key role in the transcriptional regulation of pig CAV-1
Two alternative transcript variants encode two isoforms, caveolin-1-alpha and -beta; Cav1 may be implicated in pathogenesis of Glasser's disease of swine.
The plasma membrane Na/K-ATPase (显示 ATP1A1 抗体)-caveolin-1 interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein (显示 CNBP 抗体) pathway.
The present study indicates that caveolin-containing rafts/caveolins such as caveolin-1 could play a modulating role during oligodendroglial differentiation and regeneration via NGF (显示 NGFB 抗体)/TrkA (显示 NTRK1 抗体) signaling.
Cav-1 might be a candidate gene for carcass traits, and might provide valuable information for understanding the mechanism of caveolae signaling in fat deposition by using the animal model of pig
ATRA is able to ameliorate highfatinduced AS in rabbits, which is mediated through the activation of eNOS (显示 NOS3 抗体) and downregulating CAV1 expression.
Caveolin-1 expression ameliorates nephrotic damage in a rabbit model of cholesterol-induced hypercholesterolemia.
8-Bromo-cAMP stimulated alpha-methyl-D-glucopyranoside uptake via Epac and PKA-dependent SGLTs expression and trafficking through cav-1 and F-actin in proximal tubule cells.
Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt (显示 AKT1 抗体) signaling
Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS (显示 NOS3 抗体)) expressions in high glucose cultured bovine aortic endothelial cells (BAECs).
these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS (显示 NOS3 抗体).
Study identifies a critical role of caveolin-1 in the regulation of eNOS (显示 NOS3 抗体) uncoupling via a biopterin-dependent mechanism.
Data indicate that caveolin-1 expression is required for insulin (显示 INS 抗体) uptake by aortic endothelial cells.
caveolin-1 is not required for the targeting of signaling molecules to caveolae/lipid rafts
integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk (显示 CSK 抗体) association at integrin sites, where it plays a role in downstream, shear-stimulated myelin light chain diphosphorylation.
importance of CAV1 amino acids 89-95 and particularly F92 in mediating eNOS (显示 NOS3 抗体) inhibition by AP-Cav and Cav-1
When endothelial cells were exposed to shear stress, caveolin-1 was transiently dephosphorylated.
caveolin-1 tyrosine 14 phosphorylation has a role in cell adhesion and migration
results suggest that cell division control protein 42(CDC42 (显示 CDC42 抗体)) activation is favored by the disruption of the caveolin-1-CDC42 (显示 CDC42 抗体) interaction, allowing for its participation in the regulation of capacitation and the acrosome reaction
The distribution of CAV-1 is highly dynamic during development and provides new insights into the sorting mechanisms that regulate CAV-1 localization.
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
, caveolin 1
, caveolin, caveolae protein 1
, caveolin, caveolae protein, 22 kDa
, caveolin caveolae protein 22 kDa
, vesicular integral-membrane protein VIP21
, cell growth-inhibiting protein 32
, testis derived transcript