抗Mouse (Murine) Caveolin-1 抗体:
抗Rat (Rattus) Caveolin-1 抗体:
抗Human Caveolin-1 抗体:
Human Monoclonal Caveolin-1 Primary Antibody for FACS, ICC - ABIN152046
Souto, Vallega, Wharton, Vinten, Tranum-Jensen, Pilch: Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. in The Journal of biological chemistry 2003
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Human Polyclonal Caveolin-1 Primary Antibody for IHC - ABIN965753
Maggi, Biedi, Segat, Barbero, Panetta, Cordera: IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts. in Biochemical and biophysical research communications 2002
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Monoclonal Caveolin-1 Primary Antibody for IF, IP - ABIN534131
Fork, Hitzel, Nichols, Tikkanen, Brandes: Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. in Basic research in cardiology 2014
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Human Caveolin-1 Primary Antibody for IHC - ABIN965752
Zhang, Wolf-Yadlin, Ross, Pappin, Rush, Lauffenburger, White: Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. in Molecular & cellular proteomics : MCP 2005
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Human Polyclonal Caveolin-1 Primary Antibody for ICC, IHC (fro) - ABIN3043803
Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line. in Asian Pacific journal of cancer prevention : APJCP 2013
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Dog (Canine) Polyclonal Caveolin-1 Primary Antibody for FACS, ICC - ABIN152668
Li, Liu, Pilcher, Anderson: Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria. in Journal of cell science 2001
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Human Polyclonal Caveolin-1 Primary Antibody for ICC, IHC (fro) - ABIN3044427
Shi, Li, Jia, Ji, Song, Cheng, Wu, Song, Zhang, Zhu, Yang: MicroRNA-199a-5p affects porcine preadipocyte proliferation and differentiation. in International journal of molecular sciences 2015
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Rat (Rattus) Monoclonal Caveolin-1 Primary Antibody for WB - ABIN2192105
Salani, Passalacqua, Maffioli, Briatore, Hamoudane, Contini, Cordera, Maggi: IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. in PLoS ONE 2010
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Human Polyclonal Caveolin-1 Primary Antibody for IF, WB - ABIN362044
Fielding, Chau, Liu, Spencer, Fielding: Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80. in Biochemistry 2004
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Dog (Canine) Polyclonal Caveolin-1 Primary Antibody for ELISA, WB - ABIN547469
Cavallo-Medved, Mai, Dosescu, Sameni, Sloane: Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. in Journal of cell science 2005
These results point to intestinal epithelial cell CAV1 as a potential therapeutic target to lower circulating free fatty acids and LDL cholesterol.
Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
The development of transgenic zebrafish lines expressing CLTA fused to dsRed and CAV1 fused to GFP is reported.
maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin
These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis.
interactions of cav1 at lipid-exposed domains regulate the partition of the receptor into membrane raft microdomains
Hypoxia induced migration and invasion of metastatic cancer cells require HIF1alpha-dependent induction of CAV1 expression and src family kinase activation.
Cav-1 silencing significantly reduced eIF2alpha phosphorylation and the expression of ER stress-responsive markers BiP and CHOP, which are among the known sensitizers of lipotoxicity.
Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
These findings shed light on the transcriptional mechanism by which cav-1 represses the expression of follistatin, and can inform the development of novel antifibrotic treatment strategies.
leptin promotes locomotor functional recovery and suppresses neuronal impairment after spinal cord injury (SCI) , suggesting that leptin has a promising clinical therapeutic value for treatment of SCI
Histological evaluation demonstrated that overexpression of Caveolin-1 in epidermal stem cells promoted re-epithelialization in wounds, enhanced cellularity, and increased vasculature, as well as increased wound scores.
Cav1 is a neuroprotective factor in the acute ocular hypertension injury animal model. The protective effect of Cav1 was mediated by promoting the switch of the microglial phenotype from the neurotoxic pro-inflammatory M1 to the neuroprotective anti-inflammatory M2.
Mice exposed to treadmill exercise after cerebral ischemia showed a significant up-regulation in expression of caveolin-1 compared to non-exercised animals.
Cells respond to deletion of CAV1 by increasing synthesis of extracellular matrix.
oxLDL-mediated cellular senescence is associated with increased p47phox recruitment to caveolae and its binding to Cav1.
Caloric restriction improved the metabolic phenotype in CAV-1 Knock-out mice by increasing insulin sensitivity; nevertheless, this intervention also increased Cardiovascular risk by inappropriate adaptive responses in the Renin-angiotensin-aldosterone system and Blood pressure.
Study shows that callosal projection neuron subtype-specific expression of caveolin 1 identifies and characterizes a first molecular component that distinguishes this functionally unique projection neuron population, a population that expands in primates, and is prototypical of additional dual and higher-order projection neuron subtypes.
investigation points toward CAV1 as a dysregulated protein in follicle-derived B-cell malignancies without harboring a differential expression between more aggressive and indolent hematological malignancies.
We developed a protocol to label B16F10 cells with AuNPs-PEG-TAT that permits subsequent tracking of cells in mice. CAV1 overexpression was found to increase retention and transendothelial migration of B16F10 cells in the lung.
Cav-1 deletion is able to suppress High Fat Diet-induced oxidative stress and dyslipidemia in ApoE-/- mice.
Transplantation of a denuded aorta into carotid artery leads to plaque formation. Caveolin-1 knockout leads to increased plaque formation. Additional knockout of eNOS in Cav1-/- aortae reduces plaque formation.
the CAV1-/- mice were characterized by a low-grade systemic proinflammatory status, with a moderate increase in the IL-6, TNF-alpha, and IL-12p70 levels CAV1-/- circulating lymphocytes were more prone to cytokine production upon nonspecific stimulation than the wild-type lymphocytes
data suggest that lung cancer cells escape oncogene-induced premature senescence through down-regulation of caveolin-1 expression to progress from premalignant lesions to cancer.
This study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1.
Renal Cav1 promotes water and salt reabsorption via modulation of NCC function and regulation of vascular eNOS.
findings provide experimental evidence that PTBP3 may function as a metastatic gene in gastric cancer by regulating CAV1 through alternative splicing.
autophagic degradation of Cav-1 promotes liver sinusoidal endothelial cells defenestration via inhibiting the NO-dependent pathway and F-actin remodeling.
The extracellular HMGB1 induced the migration of PMBC-derived macrophages toward HUVECs in a TLR4-dependent manner. Our results suggested that ox-LDL promoted HUVECs apoptosis and macrophage recruitment by regulating caveolin-1 phosphorylation.
The serum cav-1 level was lower in the patients with Moyamoya disease (MMD) than in the controls. In vitro analysis showed that cav-1 downregulation suppressed angiogenesis in the endothelial cells and induced apoptosis in the smooth muscle cells. Findings suggest that cav-1 may play a major role in negative arterial remodeling in MMD.
Age factor is significant in women with single nucleotide polymorphisms G32124A and T28608A of the caveolin-1 (CAV-1) gene. The relationship between cases and controls is significant for T29107A, G21985A, G14713A, and C521A polymorphisms, among which only C521A shows a significant difference in body mass index between the 2 groups.
Results show that Cav1 is overexpressed in castrationresistant prostate cancer (CRPC). Further analysis demonstrated that Cav1 expression in tumors was an independent risk factor for the occurrence of CRPC and was associated with a shorter recurrencefree survival time.
The CAV1 variation rs11773845 was found to be consistently associated with high serum triglycerides and the metabolic syndrome in an admixed Latin American population.
High CAV1 expression is associated with Tumor Invasion in Pancreatic Cancer.
ABCA1 is significantly overexpressed in patients at advanced stages of colorectal cancer, and its overexpression confers proliferative advantages together with caveolin-1 dependent-increased migratory and invasive capacities.
Co-expression of beta1 integrin and Cav1-Y14D mutant synergistically enhanced cell spreading, and focal adhesion (FA) assembly in HEK293T cells cultured on either stiff or soft matrices.
CCL5 deficiency could reverse obliterative changes in pulmonary arteries via caveolin-1-dependent amplification of BMPR2 signaling.
These results demonstrate that the interaction of Fas-ligand and caveolin-1 represents a molecular basis for Fas-ligand translocation to rafts.
Results show that Caveolin-1 was overexpressed in 25% of patients with upper tract urothelial carcinoma and was associated with adverse tumor features. Nevertheless, it could not independently predict recurrence or cancer-specific mortality.
vimentin and nestin intermediate filaments interact with caveolae central component caveolin-1 (CAV-1) and importantly, restrain the intracellular trafficking of CAV-1 positive vesicles by serving as a physical barrier.
CAV-1 was segregated in high-density lipid droplets, consistent with the formation of membrane-enclosed lipid-rich vesicular structures
these data suggested that the elevated cav-1 promoted pituitary adenoma cells migration and invasion by regulating the interaction between EGR1 and KLF5.
Caveolin-1 is palmitoylated by ZDHHC7 and ZDHHC21.
the findings of this study suggest that the downregulation of Cav1 in fibroblasts is associated with an increased tumor proliferation rate in vivo and chemoresistance. Further studies are warranted to explore whether the targeting of Cav1 in the stroma may represent a novel therapeutic approach in pancreatic cancer.
Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients.
Cav-1 stabilizes eNOS expression and regulates its activity, whereas eNOS-derived nitric oxide promotes caveola-mediated endocytosis.
Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer
transcription factor Sp1 interacts with nucleotides -123/-114, indicating that Sp1 could play a key role in the transcriptional regulation of pig CAV-1
Two alternative transcript variants encode two isoforms, caveolin-1-alpha and -beta; Cav1 may be implicated in pathogenesis of Glasser's disease of swine.
The plasma membrane Na/K-ATPase-caveolin-1 interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein pathway.
The present study indicates that caveolin-containing rafts/caveolins such as caveolin-1 could play a modulating role during oligodendroglial differentiation and regeneration via NGF/TrkA signaling.
Cav-1 might be a candidate gene for carcass traits, and might provide valuable information for understanding the mechanism of caveolae signaling in fat deposition by using the animal model of pig
ATRA is able to ameliorate highfatinduced AS in rabbits, which is mediated through the activation of eNOS and downregulating CAV1 expression.
Caveolin-1 expression ameliorates nephrotic damage in a rabbit model of cholesterol-induced hypercholesterolemia.
8-Bromo-cAMP stimulated alpha-methyl-D-glucopyranoside uptake via Epac and PKA-dependent SGLTs expression and trafficking through cav-1 and F-actin in proximal tubule cells.
Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling
Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS) expressions in high glucose cultured bovine aortic endothelial cells (BAECs).
these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS.
Study identifies a critical role of caveolin-1 in the regulation of eNOS uncoupling via a biopterin-dependent mechanism.
Data indicate that caveolin-1 expression is required for insulin uptake by aortic endothelial cells.
caveolin-1 is not required for the targeting of signaling molecules to caveolae/lipid rafts
integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myelin light chain diphosphorylation.
importance of CAV1 amino acids 89-95 and particularly F92 in mediating eNOS inhibition by AP-Cav and Cav-1
When endothelial cells were exposed to shear stress, caveolin-1 was transiently dephosphorylated.
alphaCAV1 likely contributes to control the increase in membrane signaling that occurs at the time of ovulation and luteinization.
caveolin-1 tyrosine 14 phosphorylation has a role in cell adhesion and migration
caveolin-1 Tyr(14) is necessary for binding to intermediate filaments, which in turn is required for anterior polarization of caveolin-1 in transmigrating cells
Phosphorylation of CAV1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase is reported.
XIAP plays a novel role in endothelial cells, interacting with caveolin-1 and acting as a regulator of vascular antiatherogenic function.
These data show that insulin acutely regulates eNOS and CAV-1 trafficking to plasma membrane of vascular endothelial cells where their interaction can regulate eNOS activity.
TGF-beta1 downregulates caveolin-1 of cultured endothelial cells, involving ALK-5 receptor subtype
results suggest that cell division control protein 42(CDC42) activation is favored by the disruption of the caveolin-1-CDC42 interaction, allowing for its participation in the regulation of capacitation and the acrosome reaction
These data link RABS-5 and VPS-45 ciliary functions to the processing of periciliary-derived endocytic vesicles and regulation of ciliary membrane homeostasis. Our findings also provide insight into the regulation of PKD-2 ciliary levels via integrated endosomal sorting and CAV-1-mediated endocytosis.
The distribution of CAV-1 is highly dynamic during development and provides new insights into the sorting mechanisms that regulate CAV-1 localization.
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
, caveolin 1
, caveolin, caveolae protein 1
, caveolin, caveolae protein, 22 kDa
, caveolin caveolae protein 22 kDa
, vesicular integral-membrane protein VIP21
, cell growth-inhibiting protein 32
, testis derived transcript