MATK 抗体
(Megakaryocyte-Associated tyrosine Kinase (MATK))
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Latest Publications for our MATK 抗体
: "Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration." in: International journal of oncology, Vol. 21, Issue 1, pp. 197-205, (2002) (PubMed).: "Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells." in: International journal of oncology, Vol. 21, Issue 6, pp. 1347-52, (2002) (PubMed).
: "Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer." in: The Journal of biological chemistry, Vol. 277, Issue 39, pp. 36465-70, (2002) (PubMed).
Aliases for MATK 抗体
megakaryocyte-associated tyrosine kinase (matk) 抗体megakaryocyte-associated tyrosine kinase (MATK) 抗体
megakaryocyte-associated tyrosine kinase (Matk) 抗体
zinc finger RNA binding protein 2 (ZFR2) 抗体
Batk 抗体
CHK 抗体
CTK 抗体
HHYLTK 抗体
HYL 抗体
HYLTK 抗体
Lsk 抗体
Ntk 抗体
si:ch211-63j24.2 抗体
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