(Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5))
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008].
Tang, Peng, Dong, Yang, Yang, Yang, Yang, Bao: "MARCH5 overexpression contributes to tumor growth and metastasis and associates with poor survival in breast cancer." in: Cancer management and research, Vol. 11, pp. 201-215, (2019) (PubMed).
Cilenti, Ambivero, Ward, Alnemri, Germain, Zervos: "Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy." in: Biochimica et biophysica acta, Vol. 1843, Issue 7, pp. 1295-307, (2014) (PubMed).