(Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase (MARCH2))
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]\; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010].
Han, Xiao, Kim, Wu, Wisler, Nakamura, Freedman, Shenoy: "MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound ?(2)-adrenergic receptors." in: The Journal of cell biology, Vol. 199, Issue 5, pp. 817-30, (2012) (PubMed).
Wakisaka, Tsuda, Yamada, Yagihara, Kitamura: "Long-term results of saphenous vein graft for coronary stenosis caused by Kawasaki disease." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 73, Issue 1, pp. 73-7, (2008) (PubMed).
Nakamura, Fukuda, Kato, Hirose: "MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking." in: Molecular biology of the cell, Vol. 16, Issue 4, pp. 1696-710, (2005) (PubMed).