MAP3K7 蛋白
(Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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9 results
MAP3K7
宿主: 人
宿主: 小麦胚
Recombinant
ELISA, WB, AP, AA, KAA
1 image
3 references
custom-made
MAP3K7
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
MAP3K7
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
MAP3K7
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
Latest Publications for our MAP3K7 蛋白
: "Fibroblast growth factor receptor 3 interacts with and activates TGF?-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer." in: PLoS ONE, Vol. 9, Issue 1, pp. e86470, (2014) (PubMed).: "The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner." in: Nature cell biology, Vol. 10, Issue 10, pp. 1199-207, (2008) (PubMed).
: "CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages." in: Blood, Vol. 112, Issue 13, pp. 4961-70, (2008) (PubMed).
Aliases for MAP3K7 蛋白
mitogen-activated protein kinase kinase kinase 7 (map3k7) 蛋白mitogen activated protein kinase kinase kinase 7 (Map3k7) 蛋白
mitogen-activated protein kinase kinase kinase 7 (MAP3K7) 蛋白
mitogen-activated protein kinase kinase kinase 7 (Map3k7) 蛋白
B430101B05 蛋白
C87327 蛋白
MEKK7 蛋白
si:ch211-225h9.1 蛋白
Tak1 蛋白
TAK1 蛋白
TGF1a 蛋白
zgc:110612 蛋白
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