(Mitogen-Activated Protein Kinase Kinase Kinase 6 (MAP3K6))
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008].
Cockrell, Puckett, Goldman, Khuri, Fu: "Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome." in: Oncogene, Vol. 29, Issue 6, pp. 822-30, (2010) (PubMed).
Eto, Miyagishi, Inagi, Fujita, Nangaku: "Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression." in: The American journal of pathology, Vol. 174, Issue 4, pp. 1553-63, (2009) (PubMed).
Han, Oh, Kang, Kim, Seo, Kim, Park, Kim: "Protein profiling in human sera for identification of potential lung cancer biomarkers using antibody microarray." in: Proteomics, Vol. 9, Issue 24, pp. 5544-52, (2009) (PubMed).