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(Major Basic Protein)
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The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008].
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Major Basic Protein 抗体
High quality antibodies with extensive validation data.
Major Basic Protein 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Major Basic Protein 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7428050
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7429931
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7426883
Quantity
100 μL
Datasheet
Datasheet
Recommended Major Basic Protein ELISA试剂盒
Product
Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (5)
Cat. No.
ABIN6720571
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957619
Quantity
96 tests
Datasheet
Datasheet
Recommended Major Basic Protein 蛋白
Product
Reactivity
Source
Validations
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Quantity
Datasheet
Reactivity
Pig
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394501
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394495
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405675
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Major Basic Protein Products
: "Inhibitory action of quercetin on eosinophil activation in vitro." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2013, pp. 127105, (2013) (PubMed).: "Ornithine decarboxylase as a marker for colorectal adenomas." in: The British journal of surgery, Vol. 74, Issue 11, pp. 1066, (1988) (PubMed).
Synonyms and alternative names related to Major Basic Protein
myelin basic protein (MBP), proteoglycan 2, bone marrow (Prg2), MBP, mMBP, mMBP-1Protein level used designations for Major Basic Protein
- myelin A1 protein
- myelin membrane encephalitogenic protein
- BMPG
- bone marrow proteoglycan
- major basic protein 1
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