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抗Human RAB8A 抗体:
抗Mouse (Murine) RAB8A 抗体:
抗Rat (Rattus) RAB8A 抗体:
Human Polyclonal RAB8A Primary Antibody for FACS, IHC (p) - ABIN1881723
Kato, Sekine, Oh, Kim, Umezawa, Abe, Yokoyama-Kobayashi, Aoki: Construction of a human full-length cDNA bank. in Gene 1995
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Cow (Bovine) Polyclonal RAB8A Primary Antibody for ELISA, WB - ABIN2476294
Vacca, Bazellières, Nouar, Harada, Massey-Harroche, Le Bivic: Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function. in Human molecular genetics 2014
Human Polyclonal RAB8A Primary Antibody for ELISA, WB - ABIN408690
Yoshimura, Egerer, Fuchs, Haas, Barr: Functional dissection of Rab GTPases involved in primary cilium formation. in The Journal of cell biology 2007
Rab8a is phosphorylated by LRRK2.Phosphorylation of Rab8a plays important role in the fusion and enlargement of lipid droplets.
C9ORF72 (显示 C9ORF72 抗体) causes suboptimal autophagy
GRAF1 (显示 ARHGAP26 抗体)-mediated removal of Rab8 from the cell surface restricts its activity during protrusion formation, thereby facilitating dynamic adjustment of the polarity axis.
the TNPO1 (显示 TNPO1 抗体)-Rab8-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia.
Ectopic expression of an N-terminal-truncated ARHGEF10 (显示 ARHGEF10 抗体) mutant led to the generation of large vesicle-like structures containing both Rab6 (显示 RAB6A 抗体) and Rab8.
report the design of a bioavailable StRIP3 analogue that harbors two hydrophobic cross-links and exhibits increased binding affinity, combined with robust cellular uptake and extremely high proteolytic stability. Localization experiments reveal that this double-stapled peptide and its target protein Rab8a accumulate in the same cellular compartments
knockdown of another Parkinson's disease (PD) gene, LRRK2, which phosphorylates Rab8a, similarly impairs retromer trafficking, secretory autophagy and Golgi-derived vesicle secretion, thus demonstrating converging roles of two PD genes TMEM230 and LRRK2 on Rab8a function, and suggesting that retromer and secretory dysfunction play an important role in PD pathogenesis.
Rab8 can induce Rac1- and Tiam1 (显示 TIAM1 抗体)-dependent cortical actin polymerization and focal adhesion disassembly through the proteases MT1-MMP (显示 MMP14 抗体) and calpain, and Rho-GTPase (显示 RACGAP1 抗体)-dependent mechanisms
Data demonstrate that EHBP1L1 links Rab8 and the Bin1 (显示 BIN1 抗体)-dynamin (显示 DNM1 抗体) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.
Further exploration of the NINL (显示 NINL 抗体)-associated interactome identifies MICAL3 (显示 MICAL3 抗体), a protein known to interact with Rab8 and to play an important role in vesicle docking and fusion.
Results support participation of Rab8 in OCV trafficking and identify a novel role for the TZ protein Cc2d2a (显示 CC2D2A 抗体) in fusion of incoming ciliary-directed vesicles, through organization of the vesicle fusion machinery at the periciliary membrane.
Cc2d2a (显示 CC2D2A 抗体), localized at the photoreceptor connecting cilium/transition zone, facilitates protein transport through a role in Rab8-dependent vesicle trafficking and fusion.
Data show that elipsa (显示 TRAF3IP1 抗体) encodes a coiled-coil polypeptide that localizes to cilia, and that it interacts genetically with Rabaptin5, a well-studied regulator of endocytosis, which in turn interacts with Rab8, a small GTPase (显示 RACGAP1 抗体), known to localize to cilia.
Disruption of Rab8a and Rab11a (显示 RAB11A 抗体) causes formation of basolateral microvilli in neonatal enteropathy.
The small GTPase (显示 RACGAP1 抗体) Rab8a regulates lipid uptake and storage in skeletal muscle.
Rab8a and Rab11a (显示 RAB11A 抗体) Are Dispensable for Rhodopsin (显示 RHO 抗体) Transport in Mouse Photoreceptors
With CRISPR/Cas9-mediated gene editing to stably knock out and recover Rab8a in macrophage cell lines, this study matches Akt (显示 AKT1 抗体) signaling profiles with cytokine outputs, confirming that Rab8a is a novel regulator of the Akt (显示 AKT1 抗体)/mammalian target of rapamycin (mTOR (显示 FRAP1 抗体)) pathway downstream of multiple Toll (显示 TLR4 抗体)-like Receptors.
these results indicate an indispensable role for Rab8A in insulin (显示 INS 抗体)-regulated GLUT4 (显示 SLC2A4 抗体) trafficking in C2C12 cells.
Results highlight a novel role of Rab8, downstream of IFT20, in the pathway that regulates T cell receptor (TCR) recycling, through recruiting VAMP-3 and promoting the fusion with the synaptic membrane of endosomes carrying TCR cargoes.
The small GTPase (显示 RACGAP1 抗体) Rab8 interacts with VAMP-3 (显示 VAMP3 抗体) to regulate the delivery of recycling T-cell receptors to the immune synapse.
Rab8a thus controls Wnt (显示 WNT2 抗体) delivery in producing cells and is crucial for Paneth cell maturation.
Rab8a acts as an activator of Fsp27 (显示 CIDEC 抗体)-mediated LD fusion and growth.
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
, hematopoietic SH2 domain containing
, ras-related protein Rab-8A
, RAB8A, member RAS oncogene family
, member RAS oncogene family
, Ras-related protein Rab-8A
, mel transforming oncogene (RAB8 homolog)
, mel transforming oncogene (derived from cell line NK14)
, mel transforming oncogene (derived from cell line NK14)- RAB8 homolog
, oncogene c-mel
, ras-associated protein RAB8
, RAB8, member RAS oncogene family
, cell line NK14 derived transforming oncogene