(Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Khanolkar, Kalogeropoulos, Lawrie, Roghanian, Vickers, Young: "Leukocyte Ig-Like receptor B1 restrains dendritic cell function through increased expression of the NF-κB regulator ABIN1/TNIP1." in: Journal of leukocyte biology, Vol. 100, Issue 4, pp. 737-746, (2016) (PubMed).
Manaster, Goldman-Wohl, Greenfield, Nachmani, Tsukerman, Hamani, Yagel, Mandelboim: "MiRNA-mediated control of HLA-G expression and function." in: PLoS ONE, Vol. 7, Issue 3, pp. e33395, (2012) (PubMed).
Banerjee, Lin, Skinner, Schiffhauer, Peacock, Hicks, Redmond, Morrow, Huston, Shayne, Langstein, Miller-Graziano, Strickland, ODonoghue, De: "Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression." in: Cancer research, Vol. 71, Issue 2, pp. 318-27, (2011) (PubMed).
Bankey, Banerjee, Zucchiatti, De, Sleem, Lin, Miller-Graziano, De: "Cytokine induced expression of programmed death ligands in human neutrophils." in: Immunology letters, Vol. 129, Issue 2, pp. 100-7, (2010) (PubMed).