LIG4 抗体
(Ligase IV, DNA, ATP-Dependent (LIG4))
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
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65 results
LIG4
适用: 人, Cow, 犬
WB, IHC, IF, ICC, IHC (p)
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our LIG4 抗体
: "TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency." in: Molecular cell, Vol. 74, Issue 3, pp. 466-480.e4, (2019) (PubMed).: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." in: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining." in: Nature cell biology, Vol. 19, Issue 1, pp. 68-75, (2017) (PubMed).
: "Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining." in: Nucleic acids research, Vol. 45, Issue 18, pp. 10583-10594, (2017) (PubMed).
: "An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e55493, (2013) (PubMed).
: "The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2." in: Journal of virology, Vol. 86, Issue 5, pp. 2400-15, (2012) (PubMed).
: "The HTLV-1 Tax oncoprotein represses Ku80 gene expression." in: Virology, Vol. 416, Issue 1-2, pp. 1-8, (2011) (PubMed).
Aliases for LIG4 抗体
ligase IV, DNA, ATP-dependent (lig4) 抗体DNA ligase 4 (LIG4) 抗体
DNA ligase 4 (LOC100212302) 抗体
DNA ligase 4 (CpipJ_CPIJ005161) 抗体
DNA ligase 4 (PTRG_09982) 抗体
DNA ligase 4 (MCYG_05151) 抗体
DNA ligase 4 (LOC657210) 抗体
ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4) 抗体
DNA ligase IV (ATLIG4) 抗体
ligase IV, DNA, ATP-dependent L homeolog (lig4.L) 抗体
ligase IV, DNA, ATP-dependent (Lig4) 抗体
DNA ligase 4 (Lig4) 抗体
5830471N16Rik 抗体
DNA LIGASE IV 抗体
DNL4 抗体
lig4 抗体
LIG4 抗体
lig4-A 抗体
tiny 抗体
zgc:165595 抗体
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