The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008].
Latest Publications for our Lactate Dehydrogenase A 蛋白
Lin, Muramatsu, Maedera, Tsunematsu, Hamaguchi, Koyama, Kuroda, Ono, Sawada, Yamashita: "Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis." in: EBioMedicine, Vol. 27, pp. 71-85, (2018) (PubMed).
Chung, Tsujibo, Bhattacharyya, Sharief, LI: "Genomic organization of human lactate dehydrogenase-A gene." in: The Biochemical journal, Vol. 231, Issue 3, pp. 537-41, (1986) (PubMed).
Tsujibo, Tiano, Li: "Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme." in: European journal of biochemistry / FEBS, Vol. 147, Issue 1, pp. 9-15, (1985) (PubMed).