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KLRC1 产品

(Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1))
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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Featured KLRC1 Categories

KLRC1 抗体

High quality antibodies with extensive validation data.

KLRC1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

KLRC1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KLRC1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, FACS, IHC (p)
Validations
  • (6)
Cat. No. ABIN652569
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7161640
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
Cat. No. ABIN517356
Quantity 100 μg
Datasheet Datasheet

Recommended KLRC1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730533
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730532
Quantity 96 tests
Datasheet Datasheet

Recommended KLRC1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7275339
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275338
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275335
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our KLRC1 Products

Ojo, Sharma, Liu, Moreton, Checkley-Luttge, Gupta, Lee, Lee, Otegbeye, Sekaly, de Lima, Wald: "Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells." in: Scientific reports, Vol. 9, Issue 1, pp. 14916, (2019) (PubMed).

Zou, Zuo, Yang, Fan: "The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells." in: Biochemical and biophysical research communications, Vol. 478, Issue 1, pp. 213-20, (2016) (PubMed).

Gill, Peppa, Micco, Singh, Carey, Foster, Maini, Kennedy: "Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo." in: PLoS pathogens, Vol. 12, Issue 8, pp. e1005788, (2016) (PubMed).

Loyon, Picard, Mauvais, Queiroz, Mougey, Pallandre, Galaine, Mercier-Letondal, Kellerman, Chaput, Wijdenes, Adotévi, Ferrand, Romero, Godet, Borg: "IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 1, pp. 85-96, (2016) (PubMed).

Guo, Shen, Fu, Liu, Chen, Ni, Ye, Sun, Li, Tian, Wei: "CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients." in: Scientific reports, Vol. 6, pp. 25567, (2016) (PubMed).

Kruse, Hamann, Monecke, Cyganek, Elsner, Hübscher, Walter, Streckfuss-Bömeke, Guan, Dressel: "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1." in: PLoS ONE, Vol. 10, Issue 5, pp. e0125544, (2015) (PubMed).

Roberti, Juliá, Rocca, Amat, Bravo, Loza, Coló, Loza, Fabiano, Maino, Podhorzer, Fainboim, Barrio, Mordoh, Levy: "Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade." in: European journal of immunology, Vol. 45, Issue 5, pp. 1560-9, (2015) (PubMed).

Zhao, Xu, Dai, Peng, Zhu, Shen, Zheng, Ran: "WNT5A transforms intestinal CD8αα⁺ IELs into an unconventional phenotype with pro-inflammatory features." in: BMC gastroenterology, Vol. 15, pp. 173, (2015) (PubMed).

Spallanzani, Torres, Avila, Ziblat, Iraolagoitia, Rossi, Domaica, Fuertes, Rabinovich, Zwirner: "Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 5, pp. 2141-8, (2015) (PubMed).

Picardi, Mengarelli, Marino, Gallo, Benevolo, Pescarmona, Cocco, Fraioli, Tremante, Petti, De Fabritiis, Giacomini: "Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 98, (2015) (PubMed).

Synonyms and alternative names related to KLRC1

killer cell lectin like receptor C1 (Klrc1), killer cell lectin like receptor C1 (KLRC1), NKG2-A/NKG2-B type II integral membrane protein-like (NKG2A), killer cell lectin-like receptor subfamily C, member 3 (KLRC3), killer cell lectin-like receptor subfamily C, member 1 (KLRC1), killer cell lectin-like receptor subfamily C, member 1 (Klrc1), CD159A, CD159a, KLRC1, NKG2, NKG2-A, NKG2A, NKG2B, rNKG2A

Protein level used designations for KLRC1

  • natural killer cell protein group 2-A (NKG2A)
  • CD159 antigen-like family member A
  • NK cell receptor A
  • NKG2-A/B-activating NK receptor
  • NKG2-A/NKG2-B type II integral membrane protein
  • killer cell lectin-like receptor subfamily C, member 1
  • C-lectin type II protein
  • NKG2-1/B activating NK receptor
  • NKG2-A/B type II integral membrane protein
  • natural killer cell lectin
  • natural killer group protein 2
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