Centromere B ELISA 试剂盒
适用: Various Species
Colorimetric
Sandwich ELISA
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- 抗原
- Centromere B
- 适用
- Various Species
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- Analytical Method
- Quantitative
- 产品特性
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ELISA kit for the detection of Centromere B in the research laboratory
Alternative Names: Centromere B ELISA kit
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- 应用备注
- Optimal conditions to be determined by end-user
- 板类型
- Pre-coated
- 实验流程
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AntiCentromer B is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgG class autoantibodies directed against Centromer B. The microplates can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (
- 限制
- 仅限研究用
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- 储存条件
- 4 °C
- 储存方法
- Store at 2-8 °C.
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- 抗原
- Centromere B
- 物质类
- DNA
- 背景
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In patients suffering from CREST syndrome circulating antibodies against the centromere protein B can be detected. Up to 70 % of all CREST patients exhibit anti-centromere B autoantibodies. The determination of anti-centromere B autoantibodies is of prognostic significance in diagnosing Raynaud's phenomenon. Raynaud's phenomenon often comes out as the first symptom of scleroderma and precedes the additional manifestations by several years. Also in patients suffering from primary biliary cirrhosis (PBC) anti-centromere B antibodies can be found. PBC and CREST often overlap. Anti-centromere B are found in about 10-20 % of sera from patients with PBC preferentially identifying those patients with Raynaud's phenomenon and sclerodactyly. Along with other centromere proteins (e.g. CENPA (19 kDa), CENPC (140 kDa)) centromere protein B (80 kDa) belongs to a protein complex of the chromosomal kinetochore, the attachment site of microtuble spindles during cell division.
Synonyms: Centromere B ELISA kit.
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