Anti-Prothrombin IgG/IgM ELISA 试剂盒
This 人 ELISA Kit is a Colorimetric ELISA Kit designed to quantify 人 .
Quick Overview for Anti-Prothrombin IgG/IgM ELISA 试剂盒 (ABIN930729)
抗原
Anti-Prothrombin IgG/IgM
适用
人
检测方法
Colorimetric
实验类型
Sandwich ELISA
应用范围
ELISA
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Analytical Method
- Quantitative
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产品特性
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ELISA kit for the detection of Prothrombin IgG/IgM in the research laboratory
Alternative Names: Prothrombin IgG/IgM ELISA kit
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应用备注
- Optimal conditions to be determined by end-user
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板类型
- Pre-coated
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实验流程
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The AntiProthrombin IgG/IgM is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgG or IgM class autoantibodies directed against Prothrombin. The microplate is coated with highly purified prothrombin. The microplate can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (
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限制
- 仅限研究用
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储存条件
- 4 °C
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储存方法
- Store at 2-8 °C.
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- Anti-Prothrombin IgG/IgM
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物质类
- Antibody
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背景
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Prothrombin (factor II), exerts a procoagulant activity via a prothrombinase complex, triggering fibrinogen conversion to fibrin. Autoantibodies can inhibit the formation of the thrombokinase complex. This complex is formed by the binding of prothrombin to phospholipids on the damaged cell membrane where prothrombin, then, is enzymatically transformed into thrombin. Thrombin, itself, causes blood coagulation. Antibodies directed against coagulation factors, like prothrombin, are pathogenic antibodies, that circulate in the blood stream. They directly inhibit the coagulation factors, and hence prolong the coagulation time. These autoantibodies are also found in association with autoimmune diseases. The presence of antibodies to prothrombin is associated with thrombosis in patients with SLE and APS. And it was found that high autoantibody levels against prothrombin imply a risk of deep venous thrombosis and pulmonary embolism and could be involved in the development of the thrombotic processes. Furthermore, it was demonstrated that elevated levels of antibodies to prothrombin predict a risk of myocardial infarction.
Synonyms: Prothrombin IgG/IgM ELISA kit.
抗原
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