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- 抗原 See all Clusterin (CLU) ELISA试剂盒
- Clusterin (CLU)
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适用
- 大鼠
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Clusterin
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Detected in Sertoli cells (at protein level). Detected in cultured Sertoli cells, testis, epididymis, liver and brain.
- Featured
- Discover our best selling CLU ELISA Kit
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- Discover our top product CLU ELISA Kit
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Clusterin (CLU) ELISA Kit
CLU 适用: 人 Colorimetric Sandwich ELISA 12.5 ng/mL - 800 ng/mL Cell Culture Supernatant, Cerebrospinal Fluid, Plasma, Saliva, Serum, Tissue Homogenate, Urine
Clusterin (CLU) ELISA KitCLU 适用: 小鼠 Colorimetric Sandwich ELISA 18.8 ng/mL - 1200 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 大鼠 Colorimetric Sandwich ELISA 12.5 ng/mL - 800 ng/mL Plasma, Serum, Urine
Clusterin (CLU) ELISA KitCLU 适用: 马 Colorimetric Competition ELISA 15.6 ng/mL - 1000 ng/mL Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 大鼠 Colorimetric Sandwich ELISA 6.25 ng/mL - 400 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 犬 Colorimetric Sandwich ELISA 3.12 ng/mL - 200 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: Pig Colorimetric Sandwich ELISA 1.56 ng/mL - 100 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 人 AA 23-227 Colorimetric Sandwich ELISA 0.78-50 ng/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Saliva, Serum, Urine
Clusterin (CLU) ELISA KitCLU 适用: 小鼠 AA 22-226 Colorimetric Sandwich ELISA 312-20000 pg/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Serum
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all Clusterin (CLU) ELISA试剂盒
- Clusterin (CLU)
- 别名
- Clu (CLU 产品)
- 别名
- LOC100136120 ELISA Kit, clu ELISA Kit, MGC53055 ELISA Kit, zgc:73352 ELISA Kit, xclu ELISA Kit, MGC89163 ELISA Kit, CLU ELISA Kit, APO-J ELISA Kit, APOJ ELISA Kit, CLI ELISA Kit, CLU1 ELISA Kit, CLU2 ELISA Kit, KUB1 ELISA Kit, NA1/NA2 ELISA Kit, SGP-2 ELISA Kit, SGP2 ELISA Kit, SP-40 ELISA Kit, TRPM-2 ELISA Kit, TRPM2 ELISA Kit, DAG ELISA Kit, RATTRPM2B ELISA Kit, SP40 ELISA Kit, TRPM2B ELISA Kit, Trpm2 ELISA Kit, Trpmb ELISA Kit, AI893575 ELISA Kit, ApoJ ELISA Kit, Cli ELISA Kit, D14Ucla3 ELISA Kit, Sgp-2 ELISA Kit, Sgp2 ELISA Kit, Sugp-2 ELISA Kit, GP80 ELISA Kit, gpIII ELISA Kit, 40 ELISA Kit, clusterin-1 ELISA Kit, clusterin L homeolog ELISA Kit, clusterin ELISA Kit, Clusterin ELISA Kit, LOC100136120 ELISA Kit, clu.L ELISA Kit, clu ELISA Kit, CLU ELISA Kit, clus ELISA Kit, Clu ELISA Kit, LOC101113728 ELISA Kit
- 背景
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Protein Function: Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity). .
Background: Clusterin (apolipoprotein J) is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene.This protein has several Synonyms: dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI). Clusterin was mapped to mouse chromosome 14. Clusterin is a ubiquitously expressed molecule thought to influence a variety of processes including cell death. In the brain, it accumulates in dying neurons following seizures and hypoxic-ischemic (H-I) injury. clusterin may be a new therapeutic target to modulate non-caspase-dependent neuronal death following acute brain injury.
Synonyms: Clusterin, Dimeric acid glycoprotein, DAG, Sulfated glycoprotein 2, SGP-2, Testosterone repressed prostate message 2, TRPM-2, Clusterin beta chain, Clusterin alpha chain, Clu,
Full Gene Name: clusterin
Cellular Localisation: Secreted - UniProt
- P05371
- 途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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