-
- 抗原 See all Clusterin (CLU) ELISA试剂盒
- Clusterin (CLU)
-
适用
- 大鼠
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Clusterin
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
-
Tissue Specificity: Detected in Sertoli cells (at protein level). Detected in cultured Sertoli cells, testis, epididymis, liver and brain.
- Top Product
- Discover our top product CLU ELISA Kit
-
Clusterin (CLU) ELISA Kit
CLU 适用: 人 Colorimetric Sandwich ELISA 12.5 ng/mL - 800 ng/mL Cell Culture Supernatant, Cerebrospinal Fluid, Plasma, Saliva, Serum, Tissue Homogenate, Urine
Clusterin (CLU) ELISA KitCLU 适用: 小鼠 Colorimetric Sandwich ELISA 18.8 ng/mL - 1200 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 大鼠 Colorimetric Sandwich ELISA 12.5 ng/mL - 800 ng/mL Plasma, Serum, Urine
Clusterin (CLU) ELISA KitCLU 适用: 小鼠 Colorimetric Sandwich ELISA 2.5 ng/mL - 160 ng/mL Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 马 Colorimetric Competition ELISA 15.6 ng/mL - 1000 ng/mL Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 大鼠 Colorimetric Sandwich ELISA 6.25 ng/mL - 400 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 犬 Colorimetric Sandwich ELISA 3.12 ng/mL - 200 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: Pig Colorimetric Sandwich ELISA 1.56 ng/mL - 100 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Clusterin (CLU) ELISA KitCLU 适用: 人 AA 23-227 Colorimetric Sandwich ELISA 0.78-50 ng/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Saliva, Serum, Urine
Clusterin (CLU) ELISA KitCLU 适用: 人 Colorimetric Sandwich ELISA 3.12-200 ng/mL Cell Culture Supernatant, Plasma, Saliva, Serum, Urine
-
- 板类型
- Pre-coated
- 限制
- 仅限研究用
-
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
-
- 抗原 See all Clusterin (CLU) ELISA试剂盒
- Clusterin (CLU)
- 别名
- Clu (CLU 产品)
- 背景
-
Protein Function: Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity). .
Background: Clusterin (apolipoprotein J) is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene.This protein has several Synonyms: dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI). Clusterin was mapped to mouse chromosome 14. Clusterin is a ubiquitously expressed molecule thought to influence a variety of processes including cell death. In the brain, it accumulates in dying neurons following seizures and hypoxic-ischemic (H-I) injury. clusterin may be a new therapeutic target to modulate non-caspase-dependent neuronal death following acute brain injury.
Synonyms: Clusterin, Dimeric acid glycoprotein, DAG, Sulfated glycoprotein 2, SGP-2, Testosterone repressed prostate message 2, TRPM-2, Clusterin beta chain, Clusterin alpha chain, Clu,
Full Gene Name: clusterin
Cellular Localisation: Secreted - UniProt
- P05371
- 途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
-
You are here:
