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Angiopoietin 2 ELISA 试剂盒

This 大鼠 Angiopoietin 2 ELISA Kit is a Colorimetric ELISA Kit designed to quantify 大鼠 Angiopoietin 2. This ELISA Kit has been cited in 2+ publications.
产品编号 ABIN5510731
发货至: 中国

Quick Overview for Angiopoietin 2 ELISA 试剂盒 (ABIN5510731)

抗原

See all Angiopoietin 2 (ANGPT2) ELISA试剂盒
Angiopoietin 2 (ANGPT2)

抗原表位

AA 19-496

适用

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大鼠

检测方法

Colorimetric

实验类型

Sandwich ELISA

应用范围

ELISA
  • 原理

    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Angiopoietin-2

    品牌

    PicoKine™

    Analytical Method

    Quantitative

    特异性

    Expression system for standard: NSO
    Immunogen sequence: Y19-F496

    交叉反应 (详细)

    There is no detectable cross-reactivity with other relevant proteins.
  • 板类型

    Pre-coated

    限制

    仅限研究用
  • 储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

    有效期

    12 months
  • Cai, Zhang, Huang, Sun, Qiu: "Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 924-932, (2018) (PubMed).

    Hu, Wang, Ren, Liu: "Autonomic remodeling may be responsible for decreased incidence of aortic dissection in STZ-induced diabetic rats via down-regulation of matrix metalloprotease 2." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 200, (2017) (PubMed).

  • 抗原 See all Angiopoietin 2 (ANGPT2) ELISA试剂盒

    Angiopoietin 2 (ANGPT2)

    别名

    Angpt2

    背景

    Protein Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). .

    Background: Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene. Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. ANGPT2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. Its expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

    Synonyms: Angiopoietin-2,ANG-2,Angpt2,Agpt2,

    Full Gene Name: Angiopoietin-2

    Cellular Localisation: Secreted.

    UniProt

    O35462

    途径

    RTK signaling
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