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Cardiotrophin 1 ELISA 试剂盒

This 小鼠 Cardiotrophin 1 ELISA Kit is a Colorimetric ELISA Kit designed to quantify 小鼠 Cardiotrophin 1.
产品编号 ABIN5510574
发货至: 中国

Quick Overview for Cardiotrophin 1 ELISA 试剂盒 (ABIN5510574)

抗原

See all Cardiotrophin 1 (CTF1) ELISA试剂盒
Cardiotrophin 1 (CTF1)

抗原表位

AA 2-203

适用

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小鼠

检测方法

Colorimetric

实验类型

Sandwich ELISA

应用范围

ELISA
  • 原理

    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Cardiotrophin-1

    品牌

    PicoKine™

    Analytical Method

    Quantitative

    特异性

    Expression system for standard: E.coli, Immunogen sequence: S2-A203

    交叉反应 (详细)

    There is no detectable cross-reactivity with other relevant proteins.

    产品特性

    Tissue Specificity: Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.

  • 板类型

    Pre-coated

    限制

    仅限研究用
  • 储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

    有效期

    12 months
  • 抗原 See all Cardiotrophin 1 (CTF1) ELISA试剂盒

    Cardiotrophin 1 (CTF1)

    别名

    Ctf1

    背景

    Protein Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

    Background: Cardiotrophin-1 (CT-1) is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), interleukin-6 (IL6), and interleukin-11 (IL11). And the CT-1 gene is mapped to 1p21-p13. The human CT-1 protein contains 201 amino acids and shares 80 % amino acid identity with the 203-amino acid mouse CT-1 sequence, however, unlike the mouse protein, human CT-1 has 2 rather than 1 cys and has no N-glycosylation site. Despite lacking a signal sequence, secreted CT-1 and mouse CT-1 induce cardiac myocyte hypertrophy in cell culture and bind to both mouse and human LIFR but not to OSMR. Furthermore, A 1.7-kb CT-1 transcript was detected at high levels in heart, skeletal muscle, prostate, and ovary. Low levels were detected in lung, kidney, pancreas, thymus, testis, and small intestine, with little or no expression detected in brain, placenta, spleen, colon, and peripheral blood leukocytes. And it was also observed strong expression in fetal lung and kidney.

    Synonyms: Cardiotrophin-1, CT-1, Ctf1,

    Full Gene Name: cardiotrophin 1

    Cellular Localisation: Secreted.

    UniProt

    Q60753

    途径

    JAK/STAT Signaling
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