The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
kirre like nephrin family adhesion molecule 3 (KIRREL3) 蛋白 kin of IRRE like 3 (Drosophila) (Kirrel3) 蛋白 kin of IRRE like 3 (Drosophila) (KIRREL3) 蛋白 kirre like nephrin family adhesion molecule 3 (Kirrel3) 蛋白 1500010O20Rik 蛋白 2900036G11Rik 蛋白 KIRRE 蛋白 mKIAA1867 蛋白 MRD4 蛋白 NEPH2 蛋白 PRO4502 蛋白 SST4 蛋白