This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. [provided by RefSeq, Nov 2009].
Taube, Sphyris, Johnson, Reisenauer, Nesbit, Joseph, Vijay, Sarkar, Bhangre, Song, Chang, Lee, Soundararajan, Mani: "The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition." in: Oncotarget, Vol. 8, Issue 39, pp. 65548-65565 (PubMed).