(Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 3 (KCNQ3))
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011].
Ruan, Dietrich, Liu, Zimmer, Li, Singh, Zhang, Yin, Wu, Horvath, Yang: "O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat." in: Cell, Vol. 159, Issue 2, pp. 306-17, (2014) (PubMed).
Ekberg, Schuetz, Boase, Conroy, Manning, Kumar, Poronnik, Adams: "Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2." in: The Journal of biological chemistry, Vol. 282, Issue 16, pp. 12135-42, (2007) (PubMed).
Aliases for KCNQ3 抗体
potassium voltage-gated channel subfamily Q member 3 (KCNQ3) 抗体 potassium voltage-gated channel, KQT-like subfamily, member 3 (kcnq3) 抗体 potassium voltage-gated channel subfamily Q member 3 (Kcnq3) 抗体 potassium voltage-gated channel, subfamily Q, member 3 (Kcnq3) 抗体 BFNC2 抗体 EBN2 抗体 KCNQ3 抗体 KV7.3 抗体 si:ch211-66b9.3 抗体