Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011].
González, Schell, Letcher, Veprintsev, Irvine, Williams: "Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase." in: Molecular cell, Vol. 15, Issue 5, pp. 689-701, (2004) (PubMed).
Mishra, Bhalla: "Simulations of inositol phosphate metabolism and its interaction with InsP(3)-mediated calcium release." in: Biophysical journal, Vol. 83, Issue 3, pp. 1298-316, (2002) (PubMed).
Schell, Erneux, Irvine: "Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37537-46, (2001) (PubMed).
Aliases for ITPKA 抗体
inositol-trisphosphate 3-kinase A-like (LOC564528) 抗体 Inositol-trisphosphate 3-kinase A (ip3ka) 抗体 inositol-trisphosphate 3-kinase A (ITPKA) 抗体 inositol 1,4,5-trisphosphate 3-kinase A (Itpka) 抗体 inositol-trisphosphate 3-kinase A (Itpka) 抗体 IP3-3KA 抗体 IP3KA 抗体