ISU1 蛋白
(SufE/NifU Family Protein (ISU1))
Scaffold protein for the de novo synthesis of iron- sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:15507320, PubMed:17417719). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity). {ECO:0000250|UniProtKB:Q03020, ECO:0000269|PubMed:15507320, ECO:0000269|PubMed:17417719}.
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Synonyms and alternative names related to ISU1
SufE/NifU family protein (ISU1), ATISU1, AtISU1, Protein ISCU-LIKE 1, T10I14.50, T10I14_50Protein level used designations for ISU1
- NifU-like N-terminal domain-containing protein ISU1
- NifU-like protein ISU1
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