This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010].
Fisher, Tremelling, Anderson, Gwilliam, Bumpstead, Prescott, Nimmo, Massey, Berzuini, Johnson, Barrett, Cummings, Drummond, Lees, Onnie, Hanson, Blaszczyk, Inouye, Ewels, Ravindrarajah, Keniry, Hunt et al.: "Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. ..." in: Nature genetics, Vol. 40, Issue 6, pp. 710-2, (2008) (PubMed).
Massey, Parkes: "Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease." in: Autophagy, Vol. 3, Issue 6, pp. 649-51, (2007) (PubMed).
Gozuacik, Kimchi: "Autophagy as a cell death and tumor suppressor mechanism." in: Oncogene, Vol. 23, Issue 16, pp. 2891-906, (2004) (PubMed).
Aliases for IRGM 抗体
immunity-related GTPase family M member 1 (Irgm1) 抗体 immunity-related GTPase M (Irgm) 抗体 immunity related GTPase M (IRGM) 抗体 immunity-related GTPase family M protein (LOC481473) 抗体 Ifi1 抗体 IFI1 抗体 Iigp3 抗体 Iipg3 抗体 Irgm 抗体 IRGM1 抗体 LRG-47 抗体 LRG47 抗体