IRAK4 抗体
(Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
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Latest Publications for our IRAK4 抗体
: "The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 309, Issue 7, pp. G517-27, (2015) (PubMed).: "An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. ..." in: Nature neuroscience, Vol. 15, Issue 6, pp. 827-35, (2012) (PubMed).
: "Augmentation of therapeutic responses in melanoma by inhibition of IRAK-1,-4." in: Cancer research, Vol. 72, Issue 23, pp. 6209-16, (2012) (PubMed).
: "IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18276-82, (2010) (PubMed).
: "HIV induces both a down-regulation of IRAK-4 that impairs TLR signalling and an up-regulation of the antibiotic peptide dermcidin in monocytic cells." in: Scandinavian journal of immunology, Vol. 70, Issue 3, pp. 264-76, (2009) (PubMed).
: "Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 10, pp. 6316-27, (2009) (PubMed).
: "IRAK-4--a shared NF-kappaB activator in innate and acquired immunity." in: Trends in immunology, Vol. 27, Issue 12, pp. 566-72, (2006) (PubMed).
: "The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40653-8, (2004) (PubMed).
: "Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein." in: Journal of leukocyte biology, Vol. 76, Issue 4, pp. 904-8, (2004) (PubMed).
: "Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections." in: The Journal of experimental medicine, Vol. 198, Issue 4, pp. 521-31, (2003) (PubMed).
Aliases for IRAK4 抗体
interleukin 1 receptor associated kinase 4 (IRAK4) 抗体interleukin 1 receptor associated kinase 4 (irak4) 抗体
interleukin-1 receptor-associated kinase 4 (irak4) 抗体
interleukin-1 receptor-associated kinase 4 (Irak4) 抗体
8430405M07Rik 抗体
9330209D03Rik 抗体
ipd1 抗体
IPD1 抗体
irak-4 抗体
IRAK-4 抗体
IRAK4 抗体
irak4 抗体
ny-ran-64 抗体
ny-ren-64 抗体
NY-REN-64 抗体
ren64 抗体
REN64 抗体
zgc:55553 抗体
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