The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010].
Merchant, Perkins, Boratyn, Ficociello, Wilkey, Barati, Bertram, Page, Rovin, Warram, Krolewski, Klein: "Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria." in: Journal of the American Society of Nephrology : JASN, Vol. 20, Issue 9, pp. 2065-74, (2009) (PubMed).