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SGI-1027

Inh 1020149-73-8 N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide

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产品编号 ABIN7233289

发货至: 中国

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中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

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Quick Overview for SGI-1027 (ABIN7233289)

应用范围

Inhibition (Inh)

Chemical Name

N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide

原理

DNA methyltransferase inhibitor

产品特性

Potent and selective inhibitor of DNA methyl transferase inhibiting DNMT1, DNMT3A and DNMT3B with comparable potency (IC50=12.5, 8.0 and 7.5 956M respectively). Treatment of various cancer cell lines with SGI-1027 results in selective degradation of DNMT1 (MG-132 sensitive) with minimal effect on DNMT3A and 3B at 2.5-5 μM. Prolonged treatment of RKO cells resulted in reexpression of silenced tumor suppressor genes. Synergizes with doxorubicin at growth inhibition in neuroblastoma cell lines. Disrupts the MKK3-MYC complex in cells and inhibits MYC transcriptional activity in colon and breast cancer cells.

纯度

>98 %

Formula

C27H23N7O

Solubility

Soluble in DMSO (35 mg/ml)
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