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SGI-1776 free base

InhA, Func 1025065-69-3
产品编号 ABIN3221832
发货至: 中国
  • 应用范围
    Inhibition Assay (InhA), Functional Studies (Func)
    原理
    SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
    产品特性
    Target: Pim inhibitor, FLT3 inhibitor
    Receptor: Pim1, FLT3, Pim3,Pim2
    纯化方法
    All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
    纯度
    100 %
    Formula
    C20H22F3N5O
    Solubility
    DMSO 81 mg/mL,Ethanol 81 mg/mL,Water <1 mg/mL
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Solid
    储存条件
    -20 °C
    储存方法
    For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
    Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
    Several freeze/thaw cycles should not damage the activity of our small molecule products.
    However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
    有效期
    24 months
  • 背景
    JAK/STAT Signaling
    分子量
    405.42 g/mol
    CAS-编号
    1025065-69-3
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