电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

LY2811376

InhA, Func 1194044-20-6
产品编号 ABIN4878273
发货至: 中国
  • 应用范围
    Inhibition Assay (InhA), Functional Studies (Func)
    原理
    LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
    产品特性
    Target: BACE inhibitor,Beta amyloid inhibitor, Gamma-secretase
    Receptor: BACE1, Beta Amyloid, Gamma-secretase
    纯化方法
    All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
    纯度
    99.80 %
    Formula
    C15H14F2N4S
    Solubility
    10 mM in DMSO and 200 mM in ethanol
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Solid
    储存条件
    -20 °C
    储存方法
    For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
    Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
    Several freeze/thaw cycles should not damage the activity of our small molecule products.
    However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
    有效期
    24 months
  • 背景
    Neuroscience,Proteases/Proteasome
    分子量
    320.36 g/mol
    CAS-编号
    1194044-20-6
You are here:
客服