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Insulin 产品

(Insulin (INS))
Insulin, a peptide hormone synthesized within the beta cells of the Islets of Langerhans in the pancreas, serves as a pivotal orchestrator in the intricate regulation of blood glucose concentrations. Operating through a series of intricate cellular mechanisms, insulin exerts its influence on glucose metabolism by modulating cellular glucose uptake, storage, and utilization.

Upon nutrient ingestion, particularly carbohydrates, ensuing elevated blood glucose levels trigger the release of insulin into the bloodstream. This hormone engages specific transmembrane receptors situated on target cells, namely myocytes, adipocytes, and hepatocytes.

Insulin's foremost role involves the facilitation of facilitated diffusion of glucose across cell membranes. This translocation of glucose from the extracellular milieu to the intracellular compartment facilitates its utilization as an energy substrate, predominantly discernible in muscle cells engaged in contractile activities.

Furthermore, insulin encourages glycogenesis, a process where surplus glucose is stored in the form of glycogen in hepatic and skeletal muscle cells. This endows the body with a readily mobilizable reservoir of glucose, crucial during times of heightened energy demands.

In tandem with its glycemic control functions, insulin curtails gluconeogenesis, the hepatic synthesis of glucose from non-carbohydrate precursors. By curtailing this gluconeogenic pathway, insulin safeguards against unwarranted glucose production and the concomitant elevation of blood glucose levels.

Insulin's regulatory purview extends to lipid metabolism. During periods of elevated insulin concentrations, as observed postprandially, adipocytes display an increased propensity to absorb free fatty acids and convert them into triglycerides for storage in adipose tissue depots. This, in turn, mitigates circulating fatty acid levels, averting lipotoxicity.

In addition to its cardinal involvement in carbohydrate and lipid metabolism, insulin actively influences protein metabolism. By augmenting cellular amino acid uptake, insulin provides substrates for protein synthesis, thereby contributing to tissue growth, repair, and overall nitrogen balance.

Disruptions in insulin signaling can manifest as insulin resistance, characterized by diminished cellular responsiveness to insulin's actions. This aberration is intricately linked to the pathophysiology of type 2 diabetes mellitus. Conversely, in type 1 diabetes mellitus, pancreatic beta cell dysfunction results in an absolute insulin deficiency, necessitating exogenous insulin administration for glycemic regulation.

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Featured Insulin Categories

Insulin 抗体

High quality antibodies with extensive validation data.

Insulin ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Insulin 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Insulin 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, WB, IF
Validations
  • (1)
  • (5)
Cat. No. ABIN3022885
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application ELISA, WB, IHC (p), FACS, IF (p), IF (cc), IHC (fro)
Validations
  • (1)
  • (4)
Cat. No. ABIN724265
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, WB, IF
Validations
  • (5)
Cat. No. ABIN7267886
Quantity 100 μL
Datasheet Datasheet

Recommended Insulin ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Competition ELISA
Validations
  • (36)
  • (3)
Cat. No. ABIN6574081
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
  • (8)
  • (4)
Cat. No. ABIN6574079
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
  • (14)
  • (3)
Cat. No. ABIN6574080
Quantity 96 tests
Datasheet Datasheet

Recommended Insulin 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307969
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
  • (1)
Cat. No. ABIN7284147
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (2)
Cat. No. ABIN6239790
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Insulin Products

Zhu, Mao, Wu, Yu, Cheng, Xiao, Ye, Linhardt, Orfila, Chen: "Highly Branched RG-I Domain Enrichment Is Indispensable for Pectin Mitigating against High-Fat Diet-Induced Obesity." in: Journal of agricultural and food chemistry, Vol. 68, Issue 32, pp. 8688-8701, (2021) (PubMed).

Li, Peng, Qian, Zou, Du, Wang, Zou, Feng, Zhang, Zhu, Liang, Li: "Bone Marrow-Derived Mesenchymal Stem Cells Restored High-Fat-Fed Induced Hyperinsulinemia in Rats at Early Stage of Type 2 Diabetes Mellitus." in: Cell transplantation, Vol. 29, pp. 963689720904628, (2021) (PubMed).

Song, Xia, Zhu, Xue, Fu, Hua, Hooiveld, Müller, Li et al.: "Effects of Casein, Chicken, and Pork Proteins on the Regulation of Body Fat and Blood Inflammatory Factors and Metabolite Patterns Are Largely Dependent on the Protein Level and Less Attributable to ..." in: Journal of agricultural and food chemistry, Vol. 68, Issue 35, pp. 9398-9407, (2021) (PubMed).

Sun, Zhao, Liu, Sun, Zhang, Wang, Xu, Zhang, Wang: "Modulation of Gut Microbiota by Fucoxanthin During Alleviation of Obesity in High-Fat Diet-Fed Mice." in: Journal of agricultural and food chemistry, Vol. 68, Issue 18, pp. 5118-5128, (2021) (PubMed).

Singh, Bansal, Sodhi, Khare, Bishnoi, Kondepudi, Medhi, Kuhad: "Role of TRPV1/TRPV3 channels in olanzapine-induced metabolic alteration: Possible involvement in hypothalamic energy-sensing, appetite regulation, inflammation and mesolimbic pathway." in: Toxicology and applied pharmacology, Vol. 402, pp. 115124, (2021) (PubMed).

El-Saka, Barhoma, Ibrahim, Elsaadany, Alghazaly, Elshwaikh, Marea, Madi: "Potential effect of adrenomedullin on metabolic and endocrinal dysfunctions in the experimentally induced polycystic ovary: Targeting implication of endoplasmic reticulum stress." in: Journal of biochemical and molecular toxicology, Vol. 35, Issue 5, pp. e22725, (2021) (PubMed).

Chen, Ren, Zhou, Deng, Hu, Zhang, Li: "HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice." in: British journal of pharmacology, Vol. 177, Issue 10, pp. 2286-2302, (2021) (PubMed).

Zhao, Wang, Zhu, Xia, Zhang, Wang, Zhang, Xu, Chen, Jiang, Liu, Wu, Wu, Zhang, Bai, Fotina, Hu: "The Antimicrobial Peptide Mastoparan X Protects Against Enterohemorrhagic Escherichia coli O157:H7 Infection, Inhibits Inflammation, and Enhances the Intestinal Epithelial Barrier." in: Frontiers in microbiology, Vol. 12, pp. 644887, (2021) (PubMed).

Meesaragandla, Karanth, Janke, Delcea: "Biopolymer-coated gold nanoparticles inhibit human insulin amyloid fibrillation." in: Scientific reports, Vol. 10, Issue 1, pp. 7862, (2020) (PubMed).

Yan, Chen, Zhu, Lin, Sun, Liu, Pan, Wang, Yang, Liu, Gong: "The Changes of Serum Metabolites in Diabetic GK Rats after Ileal Transposition Surgery." in: Obesity surgery, Vol. 29, Issue 3, pp. 882-890, (2020) (PubMed).

Synonyms and alternative names related to Insulin

insulin (INS), insulin (INS-IGF2), insulin (ins), insulin (Ins), insulin precursor (PIN), insulin II (Ins2), preproinsulin (ins), insulin L homeolog (ins.L), insulin S homeolog (ins.S), AA986540, IDDM2, igf2-A, ILPR, ins, Ins-2, ins-a, ins-b, ins1, ins1-a, InsII, Insulin, IRDN, Mody, Mody4, MODY10, proinsulin, xins, zgc:109842

Protein level used designations for Insulin

  • preproinsulin
  • proinsulin
  • insulin I
  • insulin
  • insulin-2
  • insa
  • insulin-like growth factor 2 (somatomedin A)
  • insulin-1
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