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IMPDH2 产品

(IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Categories

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008].

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Featured IMPDH2 Categories

IMPDH2 抗体

High quality antibodies with extensive validation data.

IMPDH2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

IMPDH2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IMPDH2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IP, RNAi
Validations
  • (1)
  • (4)
Cat. No. ABIN561488
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7156292
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (4)
Cat. No. ABIN2855167
Quantity 100 μL
Datasheet Datasheet

Recommended IMPDH2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967575
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967574
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956714
Quantity 96 tests
Datasheet Datasheet

Recommended IMPDH2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307895
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123412
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3081915
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our IMPDH2 Products

Barfeld, Fazli, Persson, Marjavaara, Urbanucci, Kaukoniemi, Rennie, Ceder, Chabes, Visakorpi, Mills: "Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer." in: Oncotarget, Vol. 6, Issue 14, pp. 12587-602, (2015) (PubMed).

Li, Meng, Liu, Li, Zhang, Bao, Song, Li: "IMPDH2 mediate radioresistance and chemoresistance in osteosarcoma cells." in: European review for medical and pharmacological sciences, Vol. 18, Issue 20, pp. 3038-44, (2014) (PubMed).

Wawrzyniak, Bianchi-Smiraglia, Bshara, Mannava, Ackroyd, Bagati, Omilian, Im, Fedtsova, Miecznikowski, Moparthy, Zucker, Zhu, Kozlova, Berman, Hoek, Gudkov, Shewach, Morrison, Nikiforov: "A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion." in: Cell reports, Vol. 5, Issue 2, pp. 493-507, (2013) (PubMed).

Nogueira da Costa, Mijal, Keen, Findlay, Wild: "Proteomic analysis of the effects of the immunomodulatory mycotoxin deoxynivalenol." in: Proteomics, Vol. 11, Issue 10, pp. 1903-14, (2011) (PubMed).

Floryk, Thompson: "Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells." in: International journal of cancer, Vol. 123, Issue 10, pp. 2294-302, (2008) (PubMed).

Mannava, Grachtchouk, Wheeler, Im, Zhuang, Slavina, Mathews, Shewach, Nikiforov: "Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 15, pp. 2392-400, (2008) (PubMed).

Fellenberg, Bernd, Delling, Witte, Zahlten-Hinguranage: "Prognostic significance of drug-regulated genes in high-grade osteosarcoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 20, Issue 10, pp. 1085-94, (2007) (PubMed).

Synonyms and alternative names related to IMPDH2

inosine monophosphate dehydrogenase 2 (IMPDH2), IMP (inosine 5'-monophosphate) dehydrogenase 2 (impdh2.S), IMP (inosine 5'-monophosphate) dehydrogenase 2 (impdh2), inosine monophosphate dehydrogenase 2 (impdh2), inosine monophosphate dehydrogenase 2 (Impdh2), inosine 5'-phosphate dehydrogenase 2 (impdh2), cb635, imp2, IMPD, impd2, IMPD2, IMPD 2, impdh-ii, IMPDH-II, impdh2, IMPDH 2, wu:fb64g02, wu:fc43f09

Protein level used designations for IMPDH2

  • IMP (inosine monophosphate) dehydrogenase 2
  • inosine monophosphate dehydrogenase 2
  • IMP (inosine 5'-monophosphate) dehydrogenase 2
  • hCG2002013-like
  • inosine-5'-monophosphate dehydrogenase 2-like
  • IMP oxireductase 2
  • IMPD 2
  • IMPDH 2
  • inosine 5' phosphate dehydrogenase 2
  • inosine monophosphate dehydrogenase type II
  • inosine-5'-monophosphate dehydrogenase 2
  • IMP dehydrogenase 2
  • IMPDH-II
  • inosine 5'-phosphate dehydrogenase 2
  • inosine 5-monophosphate dehydrogenase 2
  • IMP dehydrogenase type II
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