Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).
Tomek, Gore, Potts, Print, Black, Hallermayr, Kilian, Sattlegger, Ching: "Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation." in: Cell communication and signaling : CCS, Vol. 16, Issue 1, pp. 88, (2018) (PubMed).
Aliases for IMPACT 抗体
impact RWD domain protein (IMPACT) 抗体 impact RWD domain protein (impact) 抗体 impact (EDI_298310) 抗体 impact RWD domain protein L homeolog (impact.L) 抗体 impact RWD domain protein (Impact) 抗体 impact, RWD domain protein (Impact) 抗体 E430016J11Rik 抗体 impact-A 抗体 impact-a 抗体 RWDD5 抗体 Ximpact 抗体 zgc:103672 抗体