The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].
Chouquet, Pinto, Hennicke, Ling, Bally, Schwaigerlehner, Thielens, Kunert, Reiser: "Biophysical Characterization of the Oligomeric States of Recombinant Immunoglobulins Type-M and Their C1q-Binding Kinetics by Biolayer Interferometry." in: Frontiers in bioengineering and biotechnology, Vol. 10, pp. 816275, (2022) (PubMed).