(HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].
Hodge, Lourensz, Vaghjiani, Nguyen, Tchongue, Wang, Murthi, Sievert, Manuelpillai: "Soluble factors derived from human amniotic epithelial cells suppress collagen production in human hepatic stellate cells." in: Cytotherapy, Vol. 16, Issue 8, pp. 1132-44, (2014) (PubMed).
Shukla, Swaroop, Srivastava, Weissman: "The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression." in: Nucleic acids research, Vol. 18, Issue 8, pp. 2189, (1990) (PubMed).
Geraghty, Koller, Orr: "A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 24, pp. 9145-9, (1988) (PubMed).
Aliases for HLAG 蛋白
major histocompatibility complex, class I, G (HLA-G) 蛋白 MHC BF1 class I (BF1) 蛋白 B-F 蛋白 B-F-S04 蛋白 B-F-S05 蛋白 B-F-S06 蛋白 B-F-S07 蛋白 B-FI 蛋白 B-FIV 蛋白 BF2 蛋白 BFa2 蛋白 BFw-03 蛋白 BFw-05 蛋白 BFz-01 蛋白 MHC-G 蛋白