HMGCR 蛋白
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| HMGCR Protein (AA 700-860) (His-IF2DI Tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| HMGCR Protein (AA 1-835) (GST tag) | 人 | 小麦胚 |
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| HMGCR Protein (SUMO Tag) | 人 | 大肠杆菌（E. Coli） |
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| HMGCR Protein (AA 1-888) (Strep Tag) | 人 | Cell-free protein synthesis (CFPS) |
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| HMGCR Protein (AA 1-887) (Strep Tag) | 小鼠 | Cell-free protein synthesis (CFPS) |
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| HMGCR Protein (AA 588-887) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| HMGCR Protein (AA 638-887) (His tag) | 大鼠 | 大肠杆菌（E. Coli） |
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| HMGCR Protein (AA 588-887, partial) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| HMGCR Protein (partial) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| HMGCR Protein (AA 441-875) (His tag) | 人 | Bacteria |
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| HMGCR Protein (His tag) | 人 | 大肠杆菌（E. Coli） |
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Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- ELISA (ELISA: 所列应用)
- 质量等级
- custom-made
- 宿主
- 人
- 宿主
- Cell-free protein synthesis (CFPS)
- 蛋白类型
- Recombinant
- 纯度
- approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- ELISA (ELISA: 所列应用)
- 质量等级
- custom-made
- 宿主
- 小鼠
- 宿主
- Cell-free protein synthesis (CFPS)
- 蛋白类型
- Recombinant
- 纯度
- approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
Protein
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 大鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- SDS (SDS-PAGE: 有验证图片)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 85 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- ELISA (ELISA: 所列应用)
- Imm (Immunogen: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
Aliases for HMGCR 蛋白
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) 蛋白3-hydroxy-3-methylglutaryl-CoA reductase L homeolog (hmgcr.L) 蛋白
3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) 蛋白
3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) 蛋白
HMG Coenzyme A reductase (Hmgcr) 蛋白
3-hydroxy-3-methylglutaryl-CoA reductase b (hmgcrb) 蛋白
3H3M 蛋白
BcDNA:LD15354 蛋白
bro1 蛋白
bs32f05.y1 蛋白
CG10367 蛋白
Clb 蛋白
clb 蛋白
Dmel\\CG10367 蛋白
DmHMG-CoAr 蛋白
Hmg 蛋白
hmg-coa-r 蛋白
HMG-CoAR 蛋白
HmG-CoAR 蛋白
hmgc 蛋白
HMGCoAR 蛋白
HMGCoAr 蛋白
HMGCoARr 蛋白
HMGCR 蛋白
hmgcr 蛋白
hmgcr2 蛋白
HMGCR_Dm 蛋白
HMGR 蛋白
hmgrc 蛋白
im:6912716 蛋白
l(3)01152 蛋白
l(3)04684 蛋白
LDLCQ3 蛋白
Red 蛋白
zgc:110746 蛋白
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